COX Nicox SA

Nicox Provides First Quarter 2021 Business Update and Financial Highlights

Nicox Provides First Quarter 2021 Business Update and Financial Highlights

Press Release
Nicox Provides First Quarter 2021 Business Update and Financial Highlights




  • NCX 470 Phase 3 trials in glaucoma on track for top-line results in Q2 2022 (Mont Blanc) and Q4 2022 (Denali)
  • NCX 4251 Mississippi Phase 2b trial in blepharitis on track for top-line results in Q4 2021
    • U.S. prescriptions for VYZULTA® in Q1 2021 increased by 10.6% over Q1 2020, and for ZERVIATE® by 29.1% over Q4 2020
  • Q1 2021 net revenue of 0.6 million and cash of €42.0 million at March 31, 2021
April 19, 2021 – release at 7:30 am CET

Sophia Antipolis, France



Nicox SA (Euronext Paris: FR0013018124, COX), an international ophthalmology company, today provided a business update and financial highlights for Q1 2021 for Nicox SA and its subsidiaries (the “Nicox Group”), and updated key expected value-inflection milestones.



Key Expected Milestones



  • NCX 470 Phase 3 program in glaucoma: Nicox’s lead clinical product candidate, NCX 470, is a novel nitric oxide (NO)-donating prostaglandin analog currently in two multi-regional Phase 3 trials for the evaluation of the safety and efficacy of NCX 470 ophthalmic solution, 0.1%, against latanoprost ophthalmic solution, 0.005%, for lowering of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. Top-line results are currently expected in Q2 2022 for Mont Blanc and in Q4 2022 for Denali.  
  • NCX 4251 Phase 2b trial, Mississippi in blepharitis: NCX 4251 is a novel patented ophthalmic suspens