Ultimovacs - UV1 encouraging three-year survival data
Ultimovacs’ lead therapeutic vaccine candidate, UV1, continues to display positive signs of clinical efficacy, this time in the form of long-term patient survival from the ongoing Phase I (NCT03538314) study in advanced unresectable and metastatic malignant melanoma patients. The trial is investigating UV1 in combination with Merck’s immune checkpoint inhibitor (ICI) pembrolizumab (Keytruda) in the first-line setting. The three-year overall survival (OS) rate from patients in cohort one of the study was 71% (12/17). This result builds on the consistently high OS rates already observed from the trial: 85% (17/20) after one year and 80% (16/20) after two-year follow-up. We believe these latest data not only highlight the clinical utility of UV1 in melanoma patients, but also provide encouraging signs for further indications which UV1 is being investigated in the clinic. We continue to value Ultimovacs at NOK7.2bn or NOK209/share.Ultimovacs ASA Formerly known as Ultimovacs AS. Ultimovacs ASA, formerly Ultimovacs AS, is a Norway-based pharmaceutical company developing immunotherapies against cancer. The Company's lead product candidate is UV1, a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase. UV1 is being developed as a therapeutic cancer vaccine which may serve as a platform for use in combination with other immuno-oncology drugs which require an ongoing T cell response for their mode of action. The Company is performing a broad clinical development program with clinical trials in Europe and the USA.
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