4582 Symbio Pharmaceuticals

Edison Investment Research Limited: Edison issues outlook on SymBio Pharmaceuticals (4582)

Edison Investment Research Limited
Edison Investment Research Limited: Edison issues outlook on SymBio Pharmaceuticals (4582)

10-Sep-2020 / 08:46 GMT/BST


 

London, UK, 10 September 2020

Edison issues outlook on SymBio Pharmaceuticals (4582)

SymBio is approaching a major transition as it prepares to begin internal marketing of its lead product Treakisym (bendamustine), launch new liquid formulations of the drug and expand the market with new indications. At the same time, the company is moving past the recent clinical results from the Phase III study where rigosertib did not meet its primary endpoint and is determining the future direction of its pipeline product brincidofovir. We are taking this time to provide our clinical and commercial outlook.

 

We have lowered our valuation to ¥37.6bn or ¥1,068 per share from ¥39.0bn or ¥1,144 per share. This was driven by removing rigosertib from our models. Additionally, we have adjusted brincidofovir for the new AdV indication, which increased this program's valuation to ¥1,062m from ¥882m.


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Reports on Symbio Pharmaceuticals

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SymBio Pharmaceuticals - Termination of coverage

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SymBio Pharmaceuticals - The first whole quarter of internal SymBio sa...

SymBio reported Q121 sales of ¥1.42bn of its drug Treakisym (bendamustine) for hematologic malignancies. This is the first quarter in which the product is being sold by SymBio directly, and it marks a substantial increase over prior sales trends. Sales have more than doubled since Q420 (¥0.6bn). Part of what is driving this is the early 2021 launch of the company’s ready-to-dilute (RTD) formulation. Moreover, SymBio recently expanded the indications approved for the drug to include diffuse large...

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SymBio Pharmaceuticals - Treakisym approved for DLBCL

SymBio announced on 23 March 2021 that it has received marketing approval for Treakisym (bendamustine) for diffuse large B-cell lymphoma (DLBCL). The drug has been approved for relapsed and refractory disease in two combinations: with rituximab and polatuzumab vedotin or with rituximab alone. We expect this approval to approximately double the addressable market for the drug in Japan.

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SymBio Pharmaceuticals - Now with commercial operations

SymBio will be undergoing a major transition in 2021 as it takes back the reigns to its Treakisym (bendamustine) franchise. The company will be making it first efforts to market the product line internally in Japan following the return of the rights from Eisai in December 2020. We expect these efforts to be bolstered by the recent launch of the ready-to-dilute (RTD) formulation of the product and the upcoming approval decision for diffuse large B-cell lymphoma (DLBCL) in May 2021.

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SymBio Pharmaceuticals - Treakisym RTD approved

SymBio announced on 23 September 2020 that it has received approval from the PMDA for the ready-to-dilute (RTD) formulation of Treakisym (bendamustine) in Japan. This formulation, licensed from Eagle Pharmaceuticals, is part of SymBio’s pipeline management strategy and the company has exclusivity on the formulation until 2031. The company intends to begin marketing the product in January 2021.

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