BAI BENEVOLENTAI

BenevolentAI Announces Further Success With AstraZeneca Collaboration as Novel Heart Failure Target Selected

BenevolentAI (“BenevolentAI” or the “Company”) (Euronext Amsterdam: BAI), a leader in applying advanced AI to accelerate biopharma drug discovery, announces that AstraZeneca has added a novel target for Heart Failure to its discovery portfolio through its collaboration with BenevolentAI.

  • Novel target for Heart Failure was discovered using BenevolentAI’s AI-drug discovery platform and experimentally validated by AstraZeneca
  • First target to be selected from the extended collaboration with AstraZeneca, highlighting continued positive progress in the field of Target Identification

BenevolentAI’s strategic collaboration with AstraZeneca began in 2019, and originally focused on discovering potential new treatments for idiopathic pulmonary fibrosis (IPF) and chronic kidney disease (CKD). The collaboration was expanded in January 2022 to two new disease areas, Heart Failure and Systemic Lupus Erythematosus (SLE), demonstrating how the Benevolent Platform™ can be applied across multiple therapeutic areas.

The innovative collaboration structure sees scientists and technologists from the two companies work side-by-side, combining BenevolentAI’s AI-driven drug discovery platform and biomedical knowledge with AstraZeneca’s scientific and disease specific expertise, leading to novel and robust Target Identification. Both the initial and extended collaboration were agreed on similar terms with upfront payments on signing, research funding alongside discovery, development and commercial milestones. Additionally, the Company will receive tiered royalties on net sales of any commercialised products.

Heart Failure is a complex syndrome which occurs when the heart cannot pump enough blood around the body. It is often complicated by multiple interrelated diseases, so requires a deep understanding of the potential disease drivers in individual patients. Current heart failure treatments follow a “one-size-fits-all” approach. However, due to the wide range of mechanisms by which heart failure can occur, there remains an unmet need for new therapies as up to 50% of patients die within five years of diagnosis.

Dr Anne Phelan, Chief Scientific Officer of BenevolentAI, said:

“I am delighted that AstraZeneca has selected one of the novel Heart Failure targets that we have been jointly working on to enter its portfolio. Heart Failure is a therapeutic area where there is significant medical need but, due to the size of the market, requires a team effort and significant momentum, so we are delighted to be working with AstraZeneca in this important field of medicine.”

Regina Fritsche Danielson, SVP and Head of Research and Early Development, Cardiovascular, Renal and Metabolism, at AstraZeneca said:

“Our ongoing collaboration with BenevolentAI has been instrumental in uncovering new insights into complex diseases such as CKD and Heart Failure. This shared expertise, combined with the power of AI, has the potential to identify the right therapeutic targets for patients with heart failure and help deliver the next generation of innovative therapies.”

About BenevolentAI

At BenevolentAI (AMS: BAI), we serve patients by leveraging our proprietary and validated Benevolent Platform™ that integrates AI and science to uncover new biology, predict novel targets and develop first-in-class or best-in-class drugs for complex diseases. By applying proprietary advanced AI tools, in combination with in-house scientific expertise and wet-lab facilities, BenevolentAI is well-positioned to identify and accelerate novel drug discovery. The Company’s business model presents multiple routes for value creation, including discovery collaborations with pharma companies like AstraZeneca and Merck and advancing in-house pipelines to inflection points. Headquartered in London, with wet labs in Cambridge (UK), BenevolentAI is at the forefront of reshaping the future of drug discovery and delivering innovative medicines.

Category: non-regulatory

EN
15/05/2024

Underlying

To request access to management, click here to engage with our
partner Phoenix-IR's CorporateAccessNetwork.com

Reports on BENEVOLENTAI

 PRESS RELEASE

BenevolentAI Appoints Kenneth Mulvany as Executive Chairman

LONDON--(BUSINESS WIRE)-- BenevolentAI ("BenevolentAI" or the "Company") (Euronext Amsterdam: BAI), a leader in applying advanced AI to accelerate biopharma drug discovery and development, today announces the appointment of Kenneth (Ken) Mulvany as Executive Chairman. Dr. Joerg Moeller is stepping down as Chief Executive Officer with immediate effect. Ken Mulvany, Executive Chairman of BenevolentAI commented: “When we founded BenevolentAI, our vision was to harness the power of AI to tackle healthcare's most pressing challenges. We have since developed one of the world's most advanced and val...

 PRESS RELEASE

BenevolentAI to Present on Explainable AI for Drug Discovery at BioTec...

LONDON--(BUSINESS WIRE)-- BenevolentAI ("BenevolentAI" or the "Company") (Euronext Amsterdam: BAI), a leader in applying advanced AI to accelerate biopharma drug discovery, announces that Dr James Malone, Chief Technology Officer, will hold a presentation titled "Building Trust and Explainability in using AI in Drug Discovery" at BioTechX Europe in Basel on 10 October 2024 at 11:45 AM CET. The presentation will discuss how explainable artificial intelligence can increase transparency in drug discovery, focusing on BenevolentAI's innovative R2E (Retrieve to Explain) system. At the event, Dr Ma...

Damien Choplain ... (+3)
  • Damien Choplain
  • Marc Lavaud
  • Oussema Denguir

ODDO BHF Small & MIDCAP MORNING NEWS - 09/20/2024

Tubacex is a solutions provider for the energy and mobility sectors through high value-added products (seamless stainless-steel tubes) and services. It has recently completed a successful transformation which should result in a much more stable results and cash flow profile going forward (EBITDA margin c.15% vs 10-year historical average of 9%) although 2024 will be a transition year ahead of the completion of the ADNOC contract and the closing of Mubadala’s transaction (acquisition o...

Damien Choplain ... (+2)
  • Damien Choplain
  • Oussema Denguir

BenevolentAI : H1 2024 results contained no surprises. Out-licensing o...

>Cost-cutting plan paying off - BenevolentAI released its H1 2024 results yesterday. Our key takeaways are as follows: 1/ revenues down 46% to £ 2.8m, marked both by lower revenues from the AstraZeneca collaboration and including receipts from the recent Merck collaboration, which are expected to grow over the H2 2024-2026 period, 2/ a 39% reduction in R&D expenditure to -£ 19.5m and 3/ a reduction in SG&A expenditure of 21% to -£ 10.3m, in line with the cost-cutting ...

ResearchPool Subscriptions

Get the most out of your insights

Get in touch