Cognition Therapeutics Announces New Conversations Episode on Therapeutic Strategies to Protect the Retina in Dry AMD

PURCHASE, N.Y., Sept. 07, 2023 (GLOBE NEWSWIRE) -- , (Nasdaq: CGTX), (the “Company” or “Cognition”) has released its sixth “Conversations” video podcast, which features an interactive discussion with retinal specialists about dry age-related macular degeneration (dry AMD) and the current treatment landscape. Dry AMD is caused by a degeneration of the macula and gradual loss of central vision. An estimated 1.5 million people in the United States are affected by late-stage dry AMD, which can result in permanent vision loss.

C. Gustavo De Moraes, M.D., Ph.D., MPH, associate professor of clinical ophthalmology at Columbia University and chief medical officer of Ora, a CRO focused on ophthalmology, moderates this discussion of the pathologic drivers of dry AMD, the treatment landscape, clinical rationale for sigma-2 (σ-2) receptor modulators and the ongoing MAGNIFY phase 2 trial of CT1812 in geographic atrophy secondary to dry AMD. Panelists include , Cognition Therapeutics’ chief medical officer and two leading industry experts on research and treatment of retinal disease.

: “Geographic Atrophy: New Strategies to Protect the Retina” features:

• Jeffrey S. Heier, M.D., Director of the Vitreoretinal Service & Retina Research at Ophthalmic Consultants of Boston
• Peter K. Kaiser, M.D., FASRS, Chaney Family Endowed Chair in Ophthalmology Research and Professor of Ophthalmology at the Cleveland Clinic Lerner College of Medicine

Cognition Therapeutics welcomes comments, questions and feedback on this and other Conversations episodes which may be submitted at We’d love to hear your thoughts.

About CT1812

CT1812 is an experimental orally delivered small molecule sigma-2 (σ-2) receptor modulator designed to penetrate the blood-retinal barrier and bind selectively and saturably to the σ-2 receptor complex. The σ-2 receptor complex is involved in the regulation of key cellular processes such as membrane trafficking and autophagy that are damaged by toxic interaction with soluble beta amyloid (Aβ) oligomers, oxidative stress and other stressors. Cognition’s clinical program will assess if regulating these processes by modulating the σ-2 receptor with CT1812 can maintain homeostatic function.

About Geographic Atrophy Secondary to Dry AMD

Dry AMD, one of two forms of AMD, is common among people over 50 and is caused by degeneration and thinning of the macula, the part of the retina responsible for central vision. The gradual loss of central vision associated with dry AMD can present limitations in reading and driving. As the disease progresses in severity into geographic atrophy, degeneration of retinal pigment epithelial (RPE) cells can result in permanent vision loss.

About Cognition Therapeutics, Inc.

Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of innovative, small molecule therapeutics targeting age-related degenerative disorders of the central nervous system and retina. We are currently investigating our lead candidate CT1812 in in Alzheimer’s disease, dementia with Lewy bodies (DLB) and dry age-related macular degeneration (dry AMD). We believe CT1812 and our pipeline of σ-2 receptor modulators can regulate pathways that are impaired in these diseases. We believe that targeting the σ-2 receptor with CT1812 represents a mechanism functionally distinct from other current approaches in clinical development for the treatment of degenerative diseases. More about Cognition Therapeutics and its can be found at  

Health Care Disclaimer

Our podcast series does not constitute the practice of medical advice, diagnosis or treatment. Always talk to your health care provider for diagnosis and treatment, including your specific medical needs. If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately.

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Contact Information:

Cognition Therapeutics, Inc. 

Bill Borden (media) 

Tiberend Strategic Advisors, Inc.

Daniel Kontoh-Boateng (investors) 

Tiberend Strategic Advisors, Inc.