Lixte Biotechnology Files an IND with the FDA to Conduct a Phase 1b/2 Trial of LB-100 in Patients with Myelodysplastic Syndrome at Moffitt Cancer Center

EAST SETAUKET, NY , Oct. 09, 2018 (GLOBE NEWSWIRE) -- Lixte Biotechnology Holdings, Inc. () announced that it has submitted an IND to the FDA to conduct a Phase 1b/2 trial of the safety and therapeutic benefit of Lixte’s lead clinical compound, LB-100, in patients with low and intermediate-1 risk myelodysplastic syndrome (MDS) who have failed or are intolerant of standard treatment. The study will be conducted at Moffitt Cancer Center, Tampa, FL.

Dr. John S. Kovach, founder and CEO of Lixte, said, “We are looking forward to learning whether the anti-tumor activity of LB-100 found in preclinical models of MDS will be seen in patients with this increasingly common cancer. We are especially pleased that the study will be conducted by the expert MDS team at Moffitt, long-time leaders in this field. MDS is a complex neoplastic disorder for which new effective treatments are needed urgently. At present, there is only one drug, Revlimid (Celgene), approved for one subtype of MDS.”

About Lixte Biotechnology Holdings, Inc.

is a biotech company that identifies enzyme targets associated with serious common diseases and then designs novel compounds to attack those targets. Lixte's product pipeline is primarily focused on inhibitors of protein phosphatases, used alone and in combination with cytotoxic agents and immune checkpoint blockers.

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