Morphic Presents Positive Preclinical Data Supporting MORF-057 as an Oral Inhibitor of the α4β7 Integrin and Potential Treatment for Inflammatory Bowel Disease
Oral presentation at ECCO highlights MORF-057 as a potent, selective and orally available small molecule development candidate
Mechanism of action demonstrated in in vitro and in vivo models
WALTHAM, Mass., Feb. 14, 2020 (GLOBE NEWSWIRE) -- (NASDAQ: MORF), a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, announced an oral presentation today highlighting Morphic’s product candidate MORF-057 at the 15th Congress of the European Crohn’s and Colitis Organisation (ECCO). MORF-057 is in development as an oral inhibitor of the α4β7 integrin, a clinically proven target for the treatment of inflammatory bowel diseases (IBD).
“The approved antibody therapeutic vedolizumab has provided validation of α4β7 as an effective target for the treatment of inflammatory bowel disease. However, a significant opportunity remains to address IBD with an orally administered therapeutic,” commented Bruce Rogers, Ph.D., chief scientific officer of Morphic Therapeutic. “We are highly encouraged that the data presented at ECCO demonstrate MORF-057’s favorable in vitro pharmacodynamic characteristics and these results are reinforced by the positive outcomes in in vivo models using oral administration of MORF-057. These data further strengthen our conviction to move MORF-057 forward into clinical studies as planned.”
MORF-057 was specifically designed to inhibit α4β7-mediated migration of α4β7-expressing lymphocytes to the gut, which is a fundamental contributor to IBD. The data presented at ECCO support MORF-057 as a potent, selective and orally bioavailable small molecule inhibitor of the α4β7 integrin. In the studies presented, MORF-057 showed greater than 41,600-fold selectivity for α4β7 over α4β1.1 High specificity for α4β7 over α4β1 is necessary to avoid inhibiting α4β1, which enables potentially pathological migration of lymphocytes to the central nervous system. Further, the data demonstrate that MORF-057 acts through its intended mechanism of action, by blocking the migration of α4β7-high-expressing lymphocytes. Notably, these results were replicated in both murine and primate models, with MORF-057 activity being equivalent to the murine equivalent of vedolizumab.
Details of the Oral Presentation at ECCO 2020:
Session: Current and novel targets for IBD agents
Title: Discovery of highly selective small molecule oral inhibitors of integrin α4β7 for the treatment of inflammatory bowel diseases
Presenter: Dr. Jamie Wong, Ph.D.
Contributors: Matthew Bursavich, Natalia Blanco, Adam Camblin, Laura Cappellucci, Rhianna Cohen, Dan Cui, Megan Krumpoch, Cheng Zhong, Kristopher Hahn, Dooyoung Lee, Blaise Lippa, Fu-Yang Lin, Alex Lugovskoy, Molly McShea, Siavash Mostafavi, Terence Moy, Andrew Sullivan, Dawn Troast, Liangsu Wang, Bruce Rogers
Presentation number: DOP64
This ECCO presentation will be available on the in the Investors section.
Morphic is developing MORF-057 as a selective, oral small molecule inhibitor of the α4β7 integrin, a target for the treatment of inflammatory bowel diseases (IBD) that has been clinically validated by the success of the approved antibody therapeutic vedolizumab. α4β7 inhibition is intended to block the interactions between α4β7 on the surface of lymphocytes and the gut cell ligand MAdCAM-1, preventing lymphocyte migration from the bloodstream into intestinal mucosal tissues and causing inflammation. Morphic believes an approved oral α4β7 inhibitor has significant potential as a best-in-class medication for some types of IBD, and may offer therapeutic opportunity earlier in disease progression as a way of changing the course of disease for many patients.
About Morphic Therapeutic
Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with AbbVie, Janssen and Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit .
- ECCO presentation Wong, et al 2/14/20: selectivity was determined by comparing potency against α4β7 and α4β1 in RPMI8866 and Jurkat cell lines, respectively.
Cautionary Note Regarding Forward-Looking Statements
This press release contains “forward-looking” statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: Morphic’s plan to develop and commercialize oral small-molecule integrin therapeutics; the ability of MORF-057 or any α4β7-specific integrin inhibitors to treat inflammatory bowel disease; Morphic’s ability to fund its operations; and Morphic’s expectations about timing and ability to obtain regulatory approvals for MORF-057 or any α4β7-specific integrin inhibitors. Statements including words such as “believe,” “develop,” “support,” “plan,” “expect,” “opportunity,” or “potential” and statements in the future tense are forward-looking statements. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause our results to differ materially from those expressed or implied by such forward-looking statements. Forward-looking statements are subject to risks and uncertainties that may cause Morphic’s actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties related to Morphic’s ability to develop, obtain regulatory approval for and commercialize MORF-057 or any α4β7-specific integrin inhibitors and other product candidates, the timing and results of preclinical studies and clinical trials, Morphic’s ability to protect intellectual property; and other risks set forth in our filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof and Morphic specifically disclaims any obligation to update these forward-looking statements or reasons why actual results might differ, whether as a result of new information, future events or otherwise, except as required by law.
Tom Donovan, Ten Bridge Communications