Relief Therapeutics to Participate in Industry and Investor Conferences in May

Geneva, Switzerland, May 9, 2022 – RELIEF THERAPEUTICS Holding SA (SIX: RLF, OTCQB: RLFTF, RLFTY) (“Relief”), a biopharmaceutical company seeking to provide patients therapeutic relief from serious diseases with high unmet need, today announced participation in the following industry and investor conferences in May.

- May 16-18 (in-person)/May 23-24 (virtual partnering): Bio€quity Europe 2022. Jack Weinstein, Chief Financial Officer and Treasurer of Relief will present a company overview on May 17 at 2:30 p.m. CEST, in Milan, Italy. The Bio€quity Europe one-on-one partnering platform enables partners and investors to schedule virtual meetings. Interested parties can register at: .

- May 23-26: H.C. Wainwright Global Investment Conference. Mr. Weinstein will present a company overview at the conference on Tuesday, May 24 at 12:00 p.m. EDT. Management will host one-one-one meetings during the conference. Institutional investors who are registered for the event can log into to request a meeting with the company. An audio webcast of the presentation will be available on the Relief website at: and will be archived for a period of 90 days after the conference.

ABOUT RELIEF

Relief focuses primarily on clinical-stage programs based on molecules with a history of clinical testing and use in human patients or a strong scientific rationale. Relief’s drug candidate, RLF-100® (aviptadil), a synthetic form of Vasoactive Intestinal Peptide (VIP), is in late-stage clinical testing in the U.S. for the treatment of respiratory deficiency due to COVID-19 through Relief’s collaboration partner in the U.S., NeuroRx, Inc. Relief also has a Collaboration and License Agreement with Acer Therapeutics for the worldwide development and commercialization of ACER-001 (sodium phenylbutyrate) for the treatment of various inborn errors of metabolism, including Urea Cycle Disorders and Maple Syrup Urine Disease. Acer’s new drug application for ACER-001 for use as a treatment of urea cycle disorders was recently accepted by the FDA for filing with a PDUFA decision date of June 5, 2022. Finally, Relief's acquisitions last summer of APR Applied Pharma Research SA and AdVita Lifescience GmbH brought to Relief a diverse pipeline of marketed and development-stage programs.

RELIEF THERAPEUTICS Holding SA is listed on the SIX Swiss Exchange under the symbol RLF and quoted in the U.S. on OTCQB under the symbol RLFTF. For more information, visit . Follow us on

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