Santhera and ReveraGen to Present Efficacy and Safety Data with Vamorolone at 2022 Muscular Dystrophy Association Conference

Pratteln, Switzerland, and Rockville, MD, USA, March 15, 2022 – Santhera Pharmaceuticals (SIX: SANN) and ReveraGen BioPharma, Inc announce presentations of efficacy and tolerability data with vamorolone in Duchenne muscular dystrophy (DMD) at the 2022 Muscular Dystrophy Association (MDA) Clinical & Scientific Conference (March 13-16, 2022, Nashville, TN, USA). A rolling NDA submission to the U.S. FDA for vamorolone for the treatment of DMD is planned to start at the end of March 2022.

Evidence of clinical efficacy and safety of vamorolone in patients with DMD is based on the positive outcome of the pivotal Phase 2b VISION-DMD study and additional Phase 2a data covering a vamorolone treatment period of up to 30 months. In the VISION-DMD study, vamorolone 6 mg/kg/day met the primary endpoint at week 24, showed sustained efficacy across multiple endpoints over 48 weeks and was well tolerated with a favorable safety profile. In study participants starting on prednisone 0.75 mg/kg/day and switching to vamorolone 6 mg/kg/day after 24 weeks, efficacy was also maintained across all functional endpoints and improvements were observed on multiple safety parameters. Importantly, stunting of growth and negative effect on biomarkers of bone health observed with prednisone over the initial 24 weeks were reversed during treatment with vamorolone over the latter 24 weeks of the study. These findings align with vamorolone’s longer term durable efficacy and safety profile with the potential to offer an alternative to current standard of care. The long-term use of standard corticosteroids is associated with a series of clinically relevant side effects that often limit their use and reduce patients’ quality of life considerably.

The data will be shared at the MDA Conference as follows:

Presentation

“Vamorolone versus placebo and prednisone in Duchenne muscular dystrophy: 24-week double-blind trial VBP15-004” –March 16, 09:50-10:05 am, Tennessee Ballroom

Posters

“Delayed start analysis of efficacy outcomes in placebo to vamorolone crossover participants in VBP15-004” – poster #89

“Efficacy and safety of vamorolone during 48-week treatment in patients with Duchenne Muscular Dystrophy (DMD) in VBP15-004 study” – virtual poster

“Feasibility of switch from prednisone to vamorolone in patients with DMD in VBP15-004 study” –virtual poster

“Vamorolone vs corticosteroid real-world experience: Comparisons of 2-year treatment with NorthStar UK Network and CINRG Duchenne Natural History Study” – virtual poster

Abstracts are available on the MDA website under this .

Santhera is also hosting an on-site scientific exhibit (booth #311, located in Ryman Hall B1-2) at the conference where medical representatives of the Company will be present throughout the conference.

Santhera is planning to file a new drug application (NDA) for vamorolone in DMD with the US FDA starting at the end of March 2022 (rolling review planned). Vamorolone has been granted Orphan Drug status in the US and in Europe for DMD, and has received Fast Track and Rare Pediatric Disease designations by the US FDA and Promising Innovative Medicine (PIM) status from the UK MHRA for DMD. Vamorolone is an investigational medicine and is currently not approved for use by any health authority.

About Vamorolone

Vamorolone is a drug candidate with a novel mode of action that binds to the same receptor as corticosteroids but modifies its downstream activity and as such is a dissociative agonist [1-3]. This mechanism has the potential to ‘dissociate’ efficacy from typical steroid safety concerns and therefore vamorolone could emerge as a promising alternative to existing corticosteroids, the current standard of care in children and adolescents with DMD. In the pivotal VISION-DMD study, vamorolone met the primary endpoint Time to Stand (TTSTAND) velocity versus placebo (p=0.002) at 24 weeks of treatment and showed a good safety and tolerability profile. Compared to prednisone, vamorolone showed comparable efficacy, improvements on multiple safety parameters (including a reversal of growth impairment seen during prednisone treatment and a reduction of behavioral changes) and was associated with fewer adverse events. In clinical studies, vamorolone was generally well tolerated. The most commonly reported adverse events versus placebo from the VISION-DMD study were cushingoid features, vomiting and vitamin D deficiency. Adverse events were generally of mild to moderate severity.

References:

[1]        Heier CR at al. (2013). EMBO Mol Med 5: 1569–1585.

[2]        Reeves EKM, et al (2013). Bioorg Med Chem 21(8):2241-2249.

[3]        Liu X, et al. (2020). Proc Natl Acad Sci USA 117:24285-24293.

About Santhera

Santhera Pharmaceuticals (SIX: SANN) is a Swiss specialty pharmaceutical company focused on the development and commercialization of innovative medicines for rare neuromuscular and pulmonary diseases with high unmet medical need. Santhera has an exclusive license for all indications worldwide to vamorolone, a first-in-class dissociative steroid with novel mode of action, which was investigated in a pivotal study in patients with DMD as an alternative to standard corticosteroids. The Company is planning for filing for approval with the US FDA starting in Q1-2022. The clinical stage pipeline also includes lonodelestat to treat cystic fibrosis (CF) and other neutrophilic pulmonary diseases. Santhera out-licensed rights to its first approved product, Raxone® (idebenone), outside North America and France for the treatment of Leber's hereditary optic neuropathy (LHON) to Chiesi Group. For further information, please visit .

Raxone® is a trademark of Santhera Pharmaceuticals.

About ReveraGen BioPharma

ReveraGen was founded in 2008 to develop first-in-class dissociative steroidal drugs for Duchenne muscular dystrophy and other chronic inflammatory disorders. The development of ReveraGen’s lead compound, vamorolone, has been supported through partnerships with foundations worldwide, including Muscular Dystrophy Association USA, Parent Project Muscular Dystrophy, Foundation to Eradicate Duchenne, Save Our Sons, JoiningJack, Action Duchenne, CureDuchenne, Ryan’s Quest, Alex’s Wish, DuchenneUK, Pietro’s Fight, Michael’s Cause, Duchenne Research Fund, and Defeat Duchenne Canada. ReveraGen has also received generous support from the US Department of Defense CDMRP, National Institutes of Health (NCATS, NINDS, NIAMS), and European Commission (Horizons 2020).

For further information please contact:

Santhera

Santhera Pharmaceuticals Holding AG, Hohenrainstrasse 24, CH-4133 Pratteln

or

Eva Kalias, Head External Communications

Phone: 0

ReveraGen BioPharma

Eric Hoffman, PhD, President and CEO

Phone: 5

Disclaimer / Forward-looking statements

This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Santhera Pharmaceuticals Holding AG. This publication may contain certain forward-looking statements concerning the Company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the Company to be materially different from those expressed or implied by such statements. Readers should therefore not place undue reliance on these statements, particularly not in connection with any contract or investment decision. The Company disclaims any obligation to update these forward-looking statements.

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