vTv Therapeutics Will Participate in INNODIA Symposium at the EASD 61st Annual Meeting
Company to share new independent research on TTP-RA, vTv’s oral RAGE antagonist
HIGH POINT, N.C., Sept. 15, 2025 (GLOBE NEWSWIRE) -- vTv Therapeutics Inc. (Nasdaq: VTVT), a late-stage biopharmaceutical company, today announced that the company will present information on two of its investigational small molecules for type 1 diabetes (T1D) at the INNODIA Symposium during the European Association for the Study of Diabetes (EASD) 61st Annual Meeting. INNODIA is an international non-for-profit organization that aims to accelerate the development of therapies to prevent and cure T1D.
Carmen Valcarce, Ph.D., Executive Vice President and Chief Scientific Officer of vTv Therapeutics, will present new preclinical data from independent, researcher-run studies of TTP-RA conducted by Professor Josephine Forbes, Ph.D. of the University of Queensland. TTP-RA is vTv’s oral RAGE (Receptor for Advanced Glycation End-products) antagonist, being evaluated in combination with an anti-CD3 antibody for the prevention of T1D. vTv is actively seeking strategic partnerships to advance TTP-RA development.
At the INNODIA Symposium, Dr. Valcarce will share details of TTP-RA, including preclinical data that show TTP-RA’s ability to restore glucose homeostasis and modulate immune responses. Importantly, she will also share an update on the development of cadisegliatin, a potential first-in-class oral glucokinase activator adjunctive therapy in the ongoing Phase 3 study for the treatment for T1D (CATT1).
“While cadisegliatin advances through Phase 3 development as a potential novel adjunctive therapy for T1D patients, this preclinical data with TTP-RA represents an exciting research opportunity to potentially prevent T1D onset,” said Dr. Valcarce. “Our unique focus on small molecules differentiates vTv Therapeutics, and we are eager to partner with organizations that share our hope for TTP-RA to improve the lives of people with diabetes.”
About vTv Therapeutics
vTv Therapeutics is a late-stage biopharmaceutical company focused on developing oral, small molecule drug candidates intended to help treat people living with diabetes and other chronic diseases. vTv’s clinical pipeline is led by cadisegliatin, currently in a Phase 3 trial, a potential first-in-class oral glucokinase activator being investigated for the treatment of type 1 diabetes. vTv and its development partners are investigating multiple molecules across different indications for chronic diseases. Learn more at or follow the company on or .
About Cadisegliatin
Cadisegliatin (TTP399) is a novel, oral small molecule, liver-selective glucokinase activator being investigated as a potential first-in-class oral adjunctive treatment for type 1 diabetes (T1D). In non-clinical studies, cadisegliatin, acting selectively on the liver, increased the activity of glucokinase independently from insulin which supports clinical investigation of improvement in glycemic control through hepatic glucose uptake and glycogen storage.
Cadisegliatin is under investigation, and the safety and efficacy have not been established. There is no guarantee that this product will receive health authority approval or become commercially available for the use being investigated.
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