Active Biotech AB focuses on pharmaceutical research and development in medical fields in which the immune system plays a central role. Co. has five projects in clinical development. Three of these projects involve the development of drugs for the treatment of autoimmune/inflammatory diseases. In the laquinimod project, Co. is developing a drug to address the indications multiple sclerosis, Crohn's disease and Lupus. Paquinimod is being developed to address systemic msclerosis, and RhuDex to address primary biliary cirrhosis and rheumatoid arthritis. The project portfolio also includes two drugs for treatment of the indications renal cell cancer (ANYARA) and prostate cancer (tasquinimod).
Karo Pharma Aktiebolag is an innovative drug discovery and development company specializing in the development of novel pharmaceuticals that target nuclear receptors. Nuclear receptors are also known as transcription factors and may be regarded as on/off buttons for production of proteins, such as enzymes and receptors. The nuclear receptors control biological processes at their core level, the genetic level. The natural hormones exert the body's own very tight control of protein production. By targeting nuclear receptors, Co. tunes the body's own control systems, for instance to normalize the metabolism of lipids in patients with elevated blood cholesterol.
Orexo is a pharmaceutical company and engaged in the development and commercialization of drugs based on patented drug delivery technologies primarily in Sweden and the United States. Co.'s product portfolio includes Zubsolv® tablets for maintenance treatment of opioid dependence; Abstral® for the treatment of breakthrough pain in cancer patients; Edluar®, an active substance zolpidem and for the treatment of short-term insomnia; Diabact UBT, which is used to diagnose the presence of Helicobacter pylori, a bacterium that causes gastric ulcers; and Heliprobe System, which is a doctor's office test to detect the presence of the gastric ulcer bacterium, Helicobacter pylori.
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