Cantargia - ‘Post-Novartis’ era has begun
Novartis’s Phase III CANOPY trials with canakinumab have created (until recently) strong tail winds for the class of therapeutics targeting the IL-1 axis, including Cantargia’s lead asset CAN04 (anti-IL1RAP). Two of the CANOPY trials did not meet primary endpoints this year, which was a significant contributor for Cantargia’s share price decline. However, canakinumab’s (anti-IL1β) development has a complicated history and the read-across to Cantargia’s CAN04 (anti-IL1RAP) is not straightforward, which we examine once again in this report. We make no changes to our fundamental assumptions, as we see CAN04 as clearly differentiated from canakinumab. Cantargia has released a solid set of initial efficacy data from its own trials and has expanded its R&D programme, which will provide catalysts over the next two years. Our valuation is virtually unchanged at SEK6.91n or SEK68.9/share.Cantargia AB is a Sweden-based company engaged in development of antibody therapeutics for the treatment of leukemia. The Company is engaged in the development of a therapy for the treatment of cancer by targeting a cell-surface receptor on malignant stem cells, through the development of antibody therapeutics for eradication of malignant stem cells. Cantargia AB uses the Interleukin-1 receptor accessory protein (IL1RAP), as the target for development of a novel antibody-based therapy for leukemia.
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