Edison Investment Research - Capstone Therapeutics (CAPS) QuickView: Focus on acute pancreatitis

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Edison Investment Research

QuickView: Focus on acute pancreatitis

Capstone is investigating a promising new indication for its Apo-E mimetics triglyceride lowering in acute pancreatitis, an orphan indication with high unmet medical need and requiring only small, rapid clinical trials. AEM-28 has demonstrated significant reductions in VLDL and triglycerides in its Phase I/IIa programme and development for follow-on AEM-28-02 is underway. However, new funding will be needed to progress clinical trials.

27/04/2015 2 EN

Underlying

Capstone Therapeutics

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United States

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Edison Investment Research

Edison is an investment research and advisory company, with offices in North America, Europe, the Middle East and AsiaPac. The heart of Edison is our world renowned equity research platform and deep multi-sector expertise. At Edison Investment Research, our research is widely read by international investors, advisors and stakeholders. Edison Advisors leverages our core research platform to provide differentiated services including investor relations and strategic consulting.

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QuickView: Initial proof-of-concept established

AEM-28 has demonstrated significant reductions in both VLDL and triglycerides in the Phase I/II programme. This reinforces prior lipid biomarker trends observed in healthy volunteers. These data provide initial proof-of-concept for AEM-28, and more broadly for follow-on products within Capstoneâ€™s Apo-E mimetic pipeline including AEM-28-02, supporting progression into further trials, although additional funding will be needed. Future development could include an orphan indication, requiring only small trials for approval, in addition to potential in major CV disorders.

December 17, 2014 December 17, 2014 2 EN

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QuickView: First human lipid biomarker trends

Early data in healthy volunteers have demonstrated trends in favour of AEM-28 on a number of lipid biomarkers, even at low doses. These are the first-in-man data, which hint at potential future efficacy. AEM-28 continues to be investigated in a Phase Ib/IIa trial, with data anticipated by YE14/Q115. These could pave the way for future development in an orphan cardiovascular indication, although additional funds will likely be needed if data are positive.

September 15, 2014 September 15, 2014 2 EN

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QuickView: Focus on acute pancreatitis

QuickView: Initial proof-of-concept established

QuickView: First human lipid biomarker trends

Manx Financial Group - Termination of coverage

musicMagpie - Termination of coverage

Topps Tiles - Accelerating growth through Q125

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