Edison Investment Research - Mesoblast Ltd. (MSB) Mesoblast - A significant impact on back pain

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Edison Investment Research

Sean Conroy

Mesoblast - A significant impact on back pain

Mesoblast announced results from the MPC-06-ID trial in 391 patients with chronic low back pain due to degenerative disc disease. Patients were randomized to receive a single intra-discal injection of either rexlemestrocel-L alone or rexlemestrocel-L in combination with hyaluronic acid (HA), a vehicle thought to improve mesenchymal stromal cell (MSC) homing to inflammation sites, and saline. In the HA combination arm, statistically significant reductions in pain (as measured by a visual analog score, VAS) versus saline were seen at the 12-month (p=0.014) and 24-month (p=0.036) time points, all from a single injection.

15/03/2021 10 EN

Underlying

Mesoblast Ltd.

Mesoblast is engaged in the development of regenerative medicine products. Co. has leveraged its proprietary technology platform, based on specialized cells known as mesenchymal lineage adult stem cells ("MLCs"), to establish a portfolio of late-stage product candidates. Co.'s allogeneic, "off the shelf" product candidates target advanced stages of diseases with high, unmet medical needs including cardiovascular conditions, orthopedic disorders, immunologic and inflammatory disorders and oncology and hematologic conditions. Each MLC-derived product candidate has technical characteristics, target indications, reimbursement strategy, commercialization potential, and partnering opportunities.

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AU000000MSB8 Australian Securities Exchange Australia

Provider

Edison Investment Research

Edison is an investment research and advisory company, with offices in North America, Europe, the Middle East and AsiaPac. The heart of Edison is our world renowned equity research platform and deep multi-sector expertise. At Edison Investment Research, our research is widely read by international investors, advisors and stakeholders. Edison Advisors leverages our core research platform to provide differentiated services including investor relations and strategic consulting.

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Analysts

Sean Conroy

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Mesoblast - A significant impact on back pain

Successful Commercial Launch of Ryoncil®

Mesoblast and FDA Align on Key Items for Revascor® Biologic License Application in Ischemic Heart Failure

Mesoblast Maintains Momentum With FDA on Accelerated Approval Pathway for Revascor® in Ischemic Heart Failure and Label Extension for Ryoncil® in Adults With GvHD

Manx Financial Group - Termination of coverage

musicMagpie - Termination of coverage

Topps Tiles - Accelerating growth through Q125

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