Kinarus - A unique combination targeting unmet needs
Kinarus Therapeutics is advancing KIN001, a patented orally dosed combination of p38 mitogen-activated protein kinase (p38 MAPK) inhibitor pamapimod (in-licensed from Roche) and pioglitazone. Preclinical data suggest this combination may have antiviral, anti-inflammatory and anti-fibrotic activity. KIN001 is under development for the treatment of wet age-related macular degeneration (wet AMD), idiopathic pulmonary fibrosis (IPF) and COVID-19. Kinarus plans to start a Phase II study in wet AMD, its lead indication, before the year end, backed by preclinical data suggesting potential benefit in reducing choroidal neovascularisation (CNV) lesions. There are currently no oral drugs approved to treat wet AMD, which suggests there is a potentially significant unmet need.Perfect Holding SA. Perfect Holding SA is a Switzerland-based company that focuses on the acquisition and management of investments in companies, which are active in the aircraft management and related services sector. The Company operates under four business divisions: optical disc, aircraft management, charters and brokerage. Perfect Holding SA, through its subsidiaries, is dedicated to the provision of services to the business aircraft market such as aircraft management, aircraft sales, charter sales and travel services. The Company manages medium- to large-business aircrafts, such as Bombardier Global and Challenger jets. The Company wholly owns three subsidiaries, including Perfect Aviation SA, based in Switzerland, Perfect Aviation Portugal SA, based in Portugal and Perfect Aviation UK Ltd, based in the United Kingdom.
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