- Expanding on a proven class of anti-cancer drugs
We are initiating coverage on Sierra Oncology, a drug developer targeting the DNA damage response (DDR) network to treat cancer. The company has two Phase I trials with SRA737 targeting checkpoint kinase 1 (Chk1) in patients with genetic tumor types expected to respond to the drug. Inhibition of Chk1 is lethal in cells with defective p53 (among others), one of the most common cancer mutations, and also enhances the response to chemotherapy. Sierra also has the cell division cycle 7 (Cdc7) inhibitor SRA141 in preclinical testing. Our initial valuation is $206m or $3.95/share.Sierra Oncology is a clinical stage drug development company advancing targeted therapeutics for the treatment of patients with unmet medical needs in hematology and oncology. The company's primary drug candidate, momelotinib, which is for the treatment of myelofibrosis. The company is also advancing, SRA737, is a selective, orally bioavailable small molecule inhibitor of Checkpoint kinase 1, a main regulator of cell cycle progression and the DNA Damage Response replication stress response. The company's pipeline also includes SRA141, a selective, orally bioavailable small molecule inhibitor of cell division cycle 7 kinase.
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