Ultimovacs - UV1 by no means out after NIPU readout
Ultimovacs has reported initial clinical data from the Phase II investigator-sponsored NIPU study investigating the company’s cancer vaccine, UV1, for the treatment of relapsed/refractory (r/r) malignant pleural mesothelioma (MPM). While the study did not meet its primary endpoint of progression-free survival (PFS) following assessment conducted by a central independent review committee, local assessments at the study hospitals performed by specialist radiographers measured a statistically significant improvement in PFS. However, it is likely these assessments are not totally blinded. Importantly, a positive trend in overall survival (OS) was observed in the UV1 arm of the NIPU study; however, the clinical data needs longer to mature before definitive conclusions can be drawn from this trend. We stress that the latest results from NIPU should not be used as definitive predictors of efficacy in any of the ongoing Phase II studies for UV1. We have adjusted our valuation of Ultimovacs to reflect the latest NIPU readouts to NOK7.4bn or NOK216/share (previously NOK8.0bn or NOK234/share).Ultimovacs ASA Formerly known as Ultimovacs AS. Ultimovacs ASA, formerly Ultimovacs AS, is a Norway-based pharmaceutical company developing immunotherapies against cancer. The Company's lead product candidate is UV1, a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase. UV1 is being developed as a therapeutic cancer vaccine which may serve as a platform for use in combination with other immuno-oncology drugs which require an ongoing T cell response for their mode of action. The Company is performing a broad clinical development program with clinical trials in Europe and the USA.
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