Corbus Pharmaceuticals Presents the First Pre-Clinical Characterization of its Next Generation Nectin-4 ADC CRB-701
- CRB-701 demonstrates a differentiated nonclinical profile relative to enfortumab vedotin
- Early dose escalation clinical data supports differentiating features established pre-clinically
- The company on schedule to initiate its US study in Q1-2024
NORWOOD, Mass., Oct. 16, 2023 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (“Corbus” or the “Company”), a precision oncology company, today announced that a characterizing the pre-clinical validation of CRB-701, a next generation antibody drug conjugate (ADC) targeting nectin-4 was presented at the 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics held in Boston on October 14th 2023.
The poster, titled Development of CRB-701 (SYS6002): A novel site-specific Nectin-4 targeting ADC (Sun, et al), provides an overview of the pre-clinical development and validation of the differentiating features of CRB-701, including:
- Site specific conjugation chemistry and a stable linker that leads to low payload release in plasma.
- A novel nectin-4 targeting monoclonal antibody with improved speed of internalization and a pharmacokinetic profile that can support Q3W dosing in the clinic.
- A safety profile supports dosing at higher ADC exposures relative to enfortumab vedotin (EV).
CRB-701 demonstrates statistically significant tumor growth inhibition in preclinical models that express mid- and high-levels of nectin-4, similar to EV. However, in a low expression model, CRB-701 also exhibited statistically significant tumor growth inhibition in a primary bladder tumor model with low nectin-4 expression (H score = 50) where EV did not.
- CRB-701 has a longer half-life than EV and is being dosed on a Q3W schedule in the clinic.
- When dosed at 1.2 mg/kg CRB-701 demonstrated notably lower levels of free MMAE.
“We are excited to share for the first time the pre-clinical validation of CRB-701 that supports its exploration in the clinic. We believe that the longer half-life and lower systemic MMAE concentrations will demonstrate a meaningful benefit for patients,” said Rachael Brake Ph.D, Chief Scientific Officer of Corbus. “We were also delighted to learn that this view is also held by a number of KOLs that discussed this topic at our “ session” focused on the opportunities for development of CRB-701. The Phase 1 dose escalation in patients with Nectin-4 enriched solid tumors, being conducted in China by our partner CSPC, is nearing completion and we are on track to dose our first patient in the US in Q-1 2024.”
About Corbus
Corbus Pharmaceuticals Holdings, Inc. (the “Company” or “Corbus”) is a precision oncology company committed to helping people defeat serious illness by bringing innovative scientific approaches to well understood biological pathways. Corbus’ internal development pipeline includes CRB-701, a next generation antibody drug conjugate (ADC) that targets the expression of Nectin-4 on cancer cells to release a cytotoxic payload and CRB-601, an anti-integrin monoclonal antibody which blocks the activation of TGFβ expressed on cancer cells. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus, visit . Connect with us on , and .
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INVESTOR CONTACT:
Sean Moran
Chief Financial Officer
Corbus Pharmaceuticals
Bruce Mackle
Managing Director
LifeSci Advisors, LLC
