Ernexa Therapeutics Announces New Data to be Presented at ASCO Annual Meeting 2025
New data finds novel cell therapy successfully converts “cold” ovarian tumors into “hot,” demonstrating potential to unlock immune response and improve outcomes
CAMBRIDGE, Mass., May 28, 2025 (GLOBE NEWSWIRE) -- (Nasdaq: ERNA), developing innovative cell therapies for the treatment of advanced cancer and autoimmune disease, today announced that new data will be presented at the on June 2 in Chicago.
The study explored the technology behind Ernexa’s novel iMSC-based immunotherapy platform, which uses induced mesenchymal stem cells (iMSCs) engineered to secrete cytokines IL-7 and IL-15 directly into ovarian tumors. These iMSCs, derived from adult skin cells, safely migrated into the tumor microenvironment and triggered strong immune activation, including T cell and macrophage infiltration, turning immunologically “cold” tumors into “hot” ones.
In a syngeneic ovarian cancer mouse model, treatment with IL-7/IL-15-secreting iMSCs significantly reduced tumor burden and extended survival. The study was led by Michael Andreeff, M.D., Ph.D., from .
“This work represents the kind of breakthrough that has the potential to redefine how we treat cancer,” said Sanjeev Luther, President and CEO of Ernexa Therapeutics. “By addressing the challenge of immunologically ‘cold’ tumors – where the immune system is largely absent – we’re opening the door to more effective options for patients who currently face limited therapeutic choices. It’s a powerful validation of Ernexa’s iMSC platform and a meaningful step toward realizing the promise of innovative, scalable, and effective cell therapies.”
Details of the poster presentation session include:
Date and Time: Monday, June 2 at 1:30 PM – 4:30 PM CDT
Location: Hall A - Posters and Exhibits
Poster Title: Engineering iPSC-derived mesenchymal stem cells (i MSCs) to secrete IL-7/IL-15 for modulation of the tumor microenvironment in a "cold" ovarian tumor model
Track: Developmental Therapeutics—Immunotherapy
Sub Track: Cellular Immunotherapy
Abstract Number: 2538
Poster Board Number: 185
The abstract can also be accessed online here:
Conference attendees will have the opportunity to meet with Ernexa's Chief Scientific Officer and study author Robert Pierce, M.D., as well as the other authors, to discuss the study.
About Ernexa Therapeutics
Ernexa Therapeutics (Nasdaq: ERNA) is developing innovative cell therapies for the treatment of advanced solid tumors and autoimmune disease. Ernexa’s core technology focuses on engineering induced pluripotent stem cells (iPSCs) and transforming them into induced mesenchymal stem cells (iMSCs). Ernexa’s allogeneic synthetic iMSCs provide a scalable, off-the-shelf treatment solution, without needing patient-specific cell harvesting.
Ernexa is developing two highly innovative cell therapy products, both currently in preclinical stages. ERNA-101 is the company’s lead cell therapy product, designed to activate and regulate the immune system’s response to recognize and attack cancer cells. ERNA-102 is a cell therapy product designed to target inflammation and treat autoimmune disease. The company’s initial focus is to develop ERNA-101 for the treatment of ovarian cancer.
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Forward-Looking Statements
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