HC2 Holdings is a holding company. Through its subsidiaries, the company operates in several segments including: Construction, which is a modeler, detailer, fabricator and erector of structural steel and heavy steel plate; Marine Services, which provides engineering and underwater services on submarine cables; Energy, which designs, builds, owns, acquires, operates and maintains compressed natural gas fueling stations for transportation vehicles; Telecommunications, which operates a telecommunications business including a network of direct routes and provides voice communication services; and Insurance, which provides long-term care, life, annuity, and other accident and health coverage.

NeoGenomics operate a network of cancer-focused testing laboratories in the United States as well as laboratories in Switzerland and Singapore. The company's testing services include the following: Cytogenetics (karyotype analysis), a study of chromosomes and their relationship to disease; Fluorescence In-Situ Hybridization, a molecular cytogenetic technique that focuses on detecting and localizing the presence or absence of specific DNA sequences and genes on chromosomes; Flow cytometry, a technique utilized to measure the characteristics of cell populations; Immunohistochemistry and Digital Imaging; Molecular testing; and Morphologic analysis, a process of analyzing cells under the microscope.