Aileron Therapeutics is a biopharmaceutical company that develops and commercializes stabilized cell-permeating alpha-helical peptides to address intracellular targets in oncology and other therapeutic areas. The company's product candidate, ALRN-6924, is a cell-permeating peptide that mimics the p53 tumor suppressor protein to disrupt p53's interactions with its endogenous inhibitors, MDMX and MDM2. ALRN-6924 is designed to activate the mechanisms used by p53 in cells with non-mutant, or wild-type, p53 to regulate cell division and progression through the cell replication cycle, programmed death of cancerous cells, or apoptosis, and induction of the immune system to respond against cancer cells.
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