Aptevo Therapeutics is a biotechnology company focused on oncology (cancer) and hematology (blood disease) therapeutics. The company's core technology is the ADAPTIR? (modular protein technology) platform. The company's product candidates include: APVO436, an ADAPTIR bispecific immunotherapeutic protein targeting CD123, a cell surface receptor expressed on several hematological malignancies and CD3, a component of the T-cell receptor; APVO210, an anti-inflammatory molecule engineered using the company's ADAPTIR platform technology; and ALG.APV-527, a bispecific antibody candidate, featuring a mechanism of action designed to target 4-1BB (CD137) and 5T4, a tumor antigen overexpressed in various types of cancer.
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