Lumos Pharma is a clinical-stage immuno-oncology company develops immunotherapeutic products for the treatment of patients with cancer. The company's small-molecule product candidates in clinical development target the indoleamine-2, 3-dioxygenase (IDO) pathway, which is a pathway for cancer immune escape. These product candidates, indoximod and NLG802 (a prodrug of indoximod), are IDO pathway inhibitors with mechanisms of action that center around breaking the immune system's tolerance to cancer. The company's small molecule product candidate, NLG207, which is a nanoparticle-drug conjugate, consisting of a cyclodextrin-based polymer backbone linked to camptothecin, a topoisomerase 1 inhibitor.
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