reports
- Sean Conroy
AlzeCure Pharma - Evolving into a mid-stage biotech
Following the results released earlier this year from a Phase Ib study investigating ACD440, a topical TRPV1 antagonist for pain, AlzeCure is now preparing for a Phase II trial. Its most advanced asset in Alzheimer’s disease (AD), ACD856, a novel cognitive enhancer from its NeuroRestore platform, is now advancing through the multiple ascending dose (MAD) part of the Phase I study. In parallel, the company is also working on a second AD platform, Alzstatin, which involves γ-secretase modulators w...
- Sean Conroy
AlzeCure Pharma - Evolving into a mid-stage biotech
Following the results released earlier this year from a Phase Ib study investigating ACD440, a topical TRPV1 antagonist for pain, AlzeCure is now preparing for a Phase II trial. Its most advanced asset in Alzheimer’s disease (AD), ACD856, a novel cognitive enhancer from its NeuroRestore platform, is now advancing through the multiple ascending dose (MAD) part of the Phase I study. In parallel, the company is also working on a second AD platform, Alzstatin, which involves γ-secretase modulators w...
- Sean Conroy
AlzeCure Pharma - ACD856: Phase I progressing after SAD data
AlzeCure has provided an update on the Phase I trial for ACD856, reporting that some promising data were observed during the initial single ascending dose (SAD) part of the study. Importantly, good tolerability was observed, with the drug’s pharmacokinetic profile tracking well from preclinical and Phase 0 (micro-dosing) data. Based on these, the SAD part of the study will be expanded to investigate some higher doses as the drug’s therapeutic window might be larger than initially expected. The s...
- Sean Conroy
AlzeCure Pharma - ACD856: Phase I progressing after SAD data
AlzeCure has provided an update on the Phase I trial for ACD856, reporting that some promising data were observed during the initial single ascending dose (SAD) part of the study. Importantly, good tolerability was observed, with the drug’s pharmacokinetic profile tracking well from preclinical and Phase 0 (micro-dosing) data. Based on these, the SAD part of the study will be expanded to investigate some higher doses as the drug’s therapeutic window might be larger than initially expected. The s...
- Sean Conroy
AlzeCure Pharma - Catalysts on the horizon
AlzeCure remains on track with its evolution into a mid-stage biotech, having recently reported positive headline data from its Phase Ib trial for ACD440, topical TRPV1 antagonist for pain. The company also held an R&D event for its Painless platform highlighting assets for pain ACD440 and TrkA-NAM (preclinical). Upcoming Phase I data for ACD856, a cognitive enhancer for Alzheimer’s disease (AD), are expected in the coming months, while details about the start of a Phase IIa trial with ACD440 sh...
- Sean Conroy
AlzeCure Pharma - Positive Phase Ib with ACD440
AlzeCure has reported positive Phase Ib data for its topical treatment for neuropathic pain, ACD440, slightly earlier than expected (mid-2021). These data show that the drug was well tolerated and demonstrated an efficacy signal of its analgesic potential. Preparations for Phase II development are underway. Regulatory filling for a new study, expected by end-2021, should provide a better sense of the forms of neuropathic pain AlzeCure will pursue. We currently assume a partnering deal will occur...
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