reports
- Sean Conroy
Arovella Therapeutics - Pending patents reconfirm development of iNKT
In conjunction with Arovella Therapeutics’ strategic focus on developing its invariant natural killer T (iNKT) technology, the company has announced it has received a notification of intention from the European Patent Office for the pending patent grant for its cell platform. Management expects the patent to be granted in early 2023, after completing the formalities. Patent applications have also been filed in the United States, Canada, China, Hong Kong and Australia. If granted, the European pa...
- Sean Conroy
Arovella Therapeutics - Strategic refocus on iNKT platform
Arovella has released its activity report for Q123, the key highlight of which was the company’s decision to focus exclusively on its invariant Natural Killer T (iNKT) cell platform and cease R&D operations on its legacy OroMist platform (of which Zolpimist is the flagship asset). We consider this move as sensible as it allows Arovella to focus its resources and efforts to progress its immunoncology franchise following the in-licensing of its iNKT portfolio in mid-2021. We also believe that the ...
- Sean Conroy
Arovella Therapeutics - Positive collaboration with ALA-101
Arovella has entered into a strategic collaboration with Imugene, investigating the company’s lead cell-therapy programme CAR19-iNKT (ALA-101) with Imugene’s onCARlytics (CF33-CD19) platform in treating solid tumours. The agreement will see both companies jointly conduct pre-clinical studies for the ALA-101/CF33-CD19 combination, with initial results from the animal studies expected in H123. Combinational oncology treatment regimens are often associated with superior clinical outcomes compared t...
- Sean Conroy
Arovella Therapeutics - Progressing on all fronts
FY22 has been a year of transition for Arovella as it pivots its strategic focus towards immunotherapy, in particular invariant natural killer T (iNKT) cell-based therapies. Another major development during the period was the first commercial launch of ZolpiMist, the flagship product from its legacy OroMist portfolio. With first sales expected in Q3 CY22 for ZolpiMist and steady progress of the lead iNKT asset ALA-101 towards the clinic, we expect FY23 to be eventful for Arovella. The FY22 resul...
- Sean Conroy
Arovella Therapeutics - Recap of a busy quarter
Ahead of its FY22 results, Arovella has released its quarterly activities report, reiterating key developments and milestones achieved in the closing quarter of the financial year. While the key highlight was the signing of the manufacturing agreement with Q-Gen for its chimeric antigen receptor-invariant natural killer T (CAR-iNKT) programme ALA-101, initiation of commercial activities (with the launch of ZolpiMist in Australia) was another major milestone. Arovella also secured the US patent f...
- Sean Conroy
Arovella Therapeutics - OroMist pipeline development update
Arovella has announced the launch of ZolpiMist (an oromucosal spray for short-term insomnia) by partner STADA in Australia and the cessation by partner Strides Pharma of its development programme ALA-001 (preclinical) for an oral spray formulation of the migraine drug sumatriptan. The drugs are two of Arovella’s five pipeline assets being developed under its legacy OroMist platform, with ZolpiMist its most advanced asset. The termination of the ALA-001 programme will not have any immediate finan...
- Sean Conroy
Arovella Therapeutics - Q3 trading update confirms pipeline progressio...
Arovella’s Q322 trading update confirms the progress of its development pipeline, with an emphasis on its lead asset, ALA-101. With the selection of a contract manufacturing organisation (CMO; production of the plasmid and lentiviral vector for ALA-101 began in January 2022) and signed service agreement with Q-Gen Cell Therapeutics (to manufacture CAR-iNKT cells), the company is progressing towards clinical development. Separately, Arovella secured a US patent for the oral spray formulation of a...
- Sean Conroy
Arovella Therapeutics - Refocused pipeline towards iNKT cell therapy
Arovella is progressing on its lead product, ALA-101 (CAR19-iNKT) targeting blood cancers and has selected a CMO for the production of plasmid and lentiviral vector, with the company intending to finalise iNKT cell manufacturer in Q1 CY22. Legacy product, Zolpimist, an oro-mucosal spray for insomnia, expects to generate commercial sales in Australia (through Arovella’s partner STADA) starting from Q3 CY22. Following a recent fund raise of A$6.7m (excluding financing costs) in Q1 CY22, we estimat...
- Sean Conroy
Arovella Therapeutics - Acquiring DKK1 rights
Arovella Therapeutics (formerly SUDA Pharmaceuticals) has announced it has in-licensed the rights to a novel monoclonal antibody that targets the Dickkopf-1 (DKK1) peptide from MD Anderson Cancer Center (for undisclosed upfront and development milestones as well as single digit royalties). DKK1 has been shown to promote tumour metastasis across a variety of tumour types. The company plans to combine the DKK1 targeting technology with its recently acquired invariant natural killer T (iNKT) cell t...
- Sean Conroy
Arovella Therapeutics - Acquiring DKK1 rights
Arovella Therapeutics (formerly SUDA Pharmaceuticals) has announced it has in-licensed the rights to a novel monoclonal antibody that targets the Dickkopf-1 (DKK1) peptide from MD Anderson Cancer Center (for undisclosed upfront and development milestones as well as single digit royalties). DKK1 has been shown to promote tumour metastasis across a variety of tumour types. The company plans to combine the DKK1 targeting technology with its recently acquired invariant natural killer T (iNKT) cell t...
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