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David Nierengarten ... (+3)
  • David Nierengarten
  • Dennis Pak
  • Martin Fan
Michael Piccolo
  • Michael Piccolo

Daily Recap: ABVX, FNMA/FMCC, KLAR, PZZA, ETN, DKS, JDPE/KDP, WBD/PSKY...

Fannie Mae (FNMA - $6.01) and Freddie Mac (FMCC - $5.31)Henry Coffey States “IPO” Action Not Expected Until After the Midterms; Share Values Are Compelling. With President Trump clearly focused elsewhere and other members of the Administration unusually silent around the FNMA/FMCC “IPO,” the only d

David Nierengarten ... (+3)
  • David Nierengarten
  • Dennis Pak
  • Martin Fan
Damien Choplain ... (+2)
  • Damien Choplain
  • Oscar Haffen Lamm

M&A narrative gains momentum

We are reiterating our Buy rating on the back of the strong phase III results released Tuesday evening, which we view as a clear bull case for the company. We raise our target price to EUR68 (from EUR27), reflecting an increased probability of approval to 95% (from 70%) for obefazimod in ulcerative

Damien Choplain ... (+2)
  • Damien Choplain
  • Oscar Haffen Lamm

Successful phase III in UC, strengthening the case for strategic M&A

Abivax reported strong topline results from its phase III induction trials evaluating obefazimod in UC with a placebo-adjusted clinical remission rate of 16.4% at the 50 mg dose, exceeding market expectations of 12-13% - clearly representing a bull case for the stock. The favourable safety/tolerabi

Oscar Haffen Lamm
  • Oscar Haffen Lamm

Abivax: ABTECT enrollment complete, induction topline data expected in...

Abivax's phase 3 ABTECT trials, evaluating obefazimod in patients with moderate-to-severe UC, has completed the enrolment of a total of 1,275 patients (exceeding the target enrollment by 4%). Baseline patient characteristics of the phase 3 closely aligns with the previous phase 2b in terms of %prio

Oscar Haffen Lamm
  • Oscar Haffen Lamm

Abivax: FY'24 reiterated next key inflection points for 2025

Abivax reported today FY'2024 results which mainly focused on balance sheet items and next inflection points for its UC phase 3 trial. Patient recruitment for the phase 3 UC trial is likely on track, with full enrolment reiterated to Q2 2025 with topline results from the 8-week induction trials exp

Oscar Haffen Lamm
  • Oscar Haffen Lamm

Abivax: Takeaways from the KOL event

Abivax hosted a virtual KOL event yesterday with Dr. David T. Rubin featuring i) a discussion on the unmet medical need and current treatment landscape for patients with UC with a focus on obefazimod's MoA as a key differentiating factor, ii) a review of Obefazimod's phase 2b data as well as phase

Bruno Bulic
  • Bruno Bulic

ABIVAX: Abtect minor clinical delay

Abivax announced a minor delay in patient recruitment in its eagerly awaited Ph. III Abtect study, now guiding for a study completion in Q2 2025 (prev. Q1 2025) and a read-out in Q3 2025 (prev. Q2 2025). While the delay appears to be minor and not a primary concern in our view, we are revising our

Bruno Bulic
  • Bruno Bulic

Abivax ATM program

Abivax has announced the implementation of an At-The-Market program (ATM program) in American Depositary Shares (ADS) for an aggregate gross volume of USD150m. The ATM program will be effective for three years until November 2027. The ADS sales price is set on the volume-weighted average trading pr

Bruno Bulic
  • Bruno Bulic

Abivax Q3 2024 update

Abivax has reported uneventful Q3 results, very much focused on balance sheet items and a recap of corporate achievements this year. On financials, Abivax reiterated its cash reach to Q4 2025 (unchanged) on a cash position exiting Q3 at EUR180.5m, pointing to estimated operating expenses of EUR41.8

Bruno Bulic
  • Bruno Bulic

Abivax: Obefazimod in Crohn's disease clinical development

Abivax announced the start of clinical investigations in Crohn’s disease (CD) with obefazimod, disclosing the enrolment of the first patient. This phase IIb study (NCT06456593) named ENHANCE-CD is a multicentre, double-blind, randomized, placebo-controlled trial, with a design comparable to the com

Bruno Bulic
  • Bruno Bulic

Abivax positive long-term Ph. II data

Abivax announced excellent interim data on the long-term open-label extension phase of it’s Ph. IIb at a reduced 25mg dose od (versus 50mg od in Ph. IIb). In this extension study, patients who completed the 4-year Ph. IIa or 2-year Ph. IIb with 50mg obefazimod with clinical response could enter thi

Healthcare Team
  • Healthcare Team
Bruno Bulic
  • Bruno Bulic

Obefazimod combo partner unveiled, and monotherapy data at UEG

Abivax unveiled the identity of the first moelcule selected for development in a fixed-dose combination with obefazimod, namely Pfizer's Etrasimod (Velsipity), Pfizer launched this S1P inhibitor in Oct. 2023 in moderate to severe ulcerative colitis. Abivax pointed at intriguing synergetic effects i

Bruno Bulic
  • Bruno Bulic

H1 2024 results in-line with expectations

Abivax today reported H12024 results reporting a cash balance at EUR 222.3mn and a cash reach to Q4 2025, thereby reiterating preliminary figures provided last July. The EUR 85.2mn cash used in operation was principally driven by increased R&D spending (EUR 64.7mn) on the Phase III in UC (ABTEC

Bruno Bulic
  • Bruno Bulic

Abivax: ABTECT study enrollment on track

Abivax today provided an update on the enrollment status into its ABTECT phase III study, disclosing the enrollment of the 600th patient and confirms enrollment completion for Q1 2025 (read-out for Q2 2025).Good to know, Abivax confirmed that to date, baseline participants baseline characteristics

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