LOS ANGELES--(BUSINESS WIRE)--
Puma Biotechnology, Inc. (NASDAQ: PBYI), a biopharmaceutical company, announced publication of abstracts on neratinib for the American Association for Cancer Research (AACR) Annual Meeting 2017. The AACR Annual Meeting will be held at the Walter E. Washington Convention Center in Washington, D.C. from April 1 to April 5.
Full abstracts of the following presentations are available online at www.aacr.org:
Apr. 4, 2017, 1:00 - 5:00 p.m. EDT – Abstract 4818 (Poster):
Neratinib/fulvestrant but not fulvestrant alone maintain complete tumor
responses after treatment with trastuzumab + paclitaxel of mice bearing
ER+/HER2+ xenografts.
L.J. Schwarz et al, Vanderbilt University
Medical Center.
April 4, 2017, 1:00 - 5:00 p.m. EDT – Abstract 4157 (Poster):
Co-blockade of mTORC1, ERBB and estrogen receptor signaling pathways in
endocrine resistant breast cancer: combating tumour plasticity.
R.
Ribas et al, Institute of Cancer Research.
April 4, 2017, 1:00 - 5:00 p.m. EDT – Abstract 4038 (Poster):
Exploring optimal targeted combination therapies with neratinib for
HER2+ breast cancer.
M. Zhao et al, MD Anderson Cancer Center.
April 5, 2017, 8:00 - 12:00 p.m. EDT – Abstract 5167 (Poster):
Stem-like colorectal cancer cell lines show response to the ERK1/2
inhibitor, SCH772984, alone and in combination with neratinib while the
combination of MEK-162 and neratinib work to decrease tumor growth in
inflammatory colorectal cancer subtypes.
R. Pal et al, NSABP.
April 5, 2017, 8:00 - 12:00 p.m. EDT – Abstract 5684 (Poster):
NSABP FC-7 Correlative Study: HER2 amplification in circulating
cell-free DNA (cfDNA) in metastatic colorectal cancer (mCRC) resistant
to anti-EGFR therapy.
S. Rim Kim et al, NSABP.
Full abstracts of the following presentations are expected to be available online March 31, 2017, after 4:00 p.m. EDT:
April 2, 2017, 12:45 - 3:00 p.m. EDT – Abstract CT001 (Oral,
Clinical Trials Plenary Session): Neratinib in HER2 or HER3 mutant solid
tumors: SUMMIT, a global, multi-histology, open-label, phase 2 ‘basket’
study.
D. Hyman et al, Memorial Sloan Kettering Cancer Center.
April 2, 2017, 3:00 - 5:00 p.m. EDT – Abstract CT011 (Oral,
Minisymposium): Circulating tumor DNA (ctDNA) sequencing for HER2
mutation (HER2mut) screening and response monitoring to
neratinib in metastatic breast cancer (MBC).
C. Ma et al,
Washington University School of Medicine.
April 2, 2017, 3:00 - 5:00 p.m. EDT – Abstract CT013 (Oral,
Minisymposium): NSABP FB-10: Phase Ib dose-escalation trial evaluating
trastuzumab emtansine (T-DM1) with neratinib (N) in women with
metastatic HER2+ breast cancer (MBC).
J. Abraham et al, NSABP.
April 3, 2017, 10:30 a.m. – 12:45 p.m. EDT – Abstract LB103
(Oral, Major Symposium): Landscape of Somatic ERBB2 Mutations - Findings
from AACR GENIE and Comparison to Ongoing ERBB2 Mutant Basket Study.
A.
Schram et al, Memorial Sloan Kettering Cancer Center.
April 4, 2017, 1:00 - 5:00 p.m. EDT – Abstract CT128 (Poster):
Effects of adding budesonide or colestipol to loperamide prophylaxis on
neratinib-associated diarrhea in patients (pts) with HER2+ early-stage
breast cancer (eBC): the CONTROL trial.
E. Ibrahim et al, Beaver
Medical Group LP.
About Puma Biotechnology:
Puma Biotechnology, Inc. is a biopharmaceutical company with a focus on the development and commercialization of innovative products to enhance cancer care. The Company in-licenses the global development and commercialization rights to three drug candidates—PB272 (neratinib (oral)), PB272 (neratinib (intravenous)) and PB357. Neratinib is a potent irreversible tyrosine kinase inhibitor that blocks signal transduction through the epidermal growth factor receptors, HER1, HER2 and HER4. Currently, the Company is primarily focused on the development of the oral version of neratinib, and its most advanced drug candidates are directed at the treatment of HER2-positive breast cancer. The Company believes that neratinib has clinical application in the treatment of several other cancers as well, including non-small cell lung cancer and other tumor types that over-express or have a mutation in HER2.
Further information about Puma Biotechnology may be found at www.pumabiotechnology.com.
Forward-Looking Statements:
This press release contains forward-looking statements that involve risks and uncertainties that could cause the Company's actual results to differ materially from the anticipated results and expectations expressed in these forward-looking statements. These statements are based on current expectations, forecasts and assumptions, and actual outcomes and results could differ materially from these statements due to a number of factors, which include, but are not limited to, the risk factors disclosed in the periodic reports filed by the Company with the Securities and Exchange Commission from time to time. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. The Company assumes no obligation to update these forward-looking statements, except as required by law.
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