Update: Novartis extends manufacturing collaboration
Novartis has broadened the terms of its CTL019/CART-019 manufacturing collaboration with Oxford BioMedica, with additional incentives for capacity expansion and process optimisation. The new agreement includes $14m upfront, of which $4.3m is an equity stake, with potential to receive a total of $90m over the next three years if the objectives are met. The deal clearly validates both the LentiVector platform and, equally importantly, the production skills and technical expertise being developed.Oxford BioMedica is a producer of gene and cell therapy in lentiviral vector and cell therapy research, development and production. Gene and cell therapy is the treatment of disease by the delivery of therapeutic deoxyribonucleic acid into a patient's cells. This can be achieved either in vivo (referred to as gene therapy) or ex vivo (referred to as cell therapy), the latter being where patients' cells are genetically modified cells outside the body before being re-infused. Co.'s products include: OXB-102, which targets Parkinson's disease; OXB-202, which targets corneal graft rejection; and OXB-302 (CAR-T 5T4), which targets targets a range of cancers.
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