Knight Therapeutics and Helsinn Healthcare SA Expand Relationship and Enter into Exclusive License, Distribution, and Supply Agreement for Onicit®
MONTREAL and LUGANO, Switzerland, Jan. 28, 2025 (GLOBE NEWSWIRE) -- Knight Therapeutics Inc. (TSX: GUD) (“Knight”), a pan-American (ex-USA) specialty pharmaceutical company, and Helsinn Healthcare SA (“Helsinn”), a global pharmaceutical company with a track record of over forty-five years of commercial execution and a strong focus in supportive care, oncology and dermato-oncology, today announced that Knight, through one of its wholly-owned subsidiaries, and Helsinn have expanded their existing relationship and have entered into an exclusive license, distribution and supply agreement (“Agreement”) for ONICIT® IV (palonosetron) in Mexico, Brazil, and other LATAM countries. ONICIT® is marketed under the brand name ALOXI® in Canada.
Under the terms of the Agreement, Knight shall have the exclusive license rights to distribute, promote, market and sell ONICIT® in the licensed territories. Knight will begin commercial activities following a transition period from Helsinn’s previous licensee.
Knight and Helsinn had entered into an exclusive license, distribution and supply agreement for AKYNZEO® oral/IV (netupitant/palonosetron / fosnetupitant/palonosetron) in Canada, Brazil, Argentina, Uruguay and Paraguay, and ALOXI® oral/IV (palonosetron) in Canada, in May 2022.
“We are very excited to expand our collaboration with Helsinn with the addition of ONICIT® for Mexico, Brazil and other countries in Latin America,” said Samira Sakhia, President and CEO of Knight. “ONICIT® is highly synergistic with AKYNZEO® as well as the rest of our oncology portfolio and commercial footprint, and we look forward to widening access to this product in our target markets.”
“Helsinn is dedicated to enhancing the quality of life for cancer patients through our supportive care products”, said Dr. Melanie Rolli, Helsinn CEO. “Knight is a trusted partner with an excellent footprint in Canada and Latin America and a shared commitment to providing the best treatment options for people with cancer and we are delighted to be working alongside them.”
About ONICIT®
ONICIT® is a second generation 5-HT3 receptor antagonist with higher affinity for the 5-HT3 receptor compared to first-generation 5-HT3 receptor antagonists.1 A single dose of ONICIT® prior to chemotherapy provides protection over the entire overall phase (days 1–5) hence providing a simple, yet effective, regimen. Efficacy was demonstrated both in the acute (day 1) and in the delayed (days 2-5) phase after chemotherapy.2,3 ONICIT® solution for injection is approved and marketed in Brazil and Mexico for the prevention of acute nausea and vomiting associated with the initial and repeated cycles of moderately and highly emetogenic chemotherapy for cancer, and for the prevention of delayed nausea and vomiting associated with the initial and repeated cycles of moderately emetogenic chemotherapy for cancer. Additionally, ONICIT® is indicated for the prevention of postoperative nausea and vomiting (PONV), for up to 24 hours after surgery.
In Brazil, ONICIT® is also indicated for pediatric patients, from 1 month to 17 years of age, for the prevention of acute nausea and vomiting associated with the initial and repeated cycles of emetogenic chemotherapy for cancer, including highly emetogenic chemotherapy.
References
1 Rojas C, Slusher BS. Pharmacological mechanisms of 5-HT₃ and tachykinin NK₁ receptor antagonism to prevent chemotherapy-induced nausea and vomiting. Eur J Pharmacol. 2012;684(1-3):1-7. doi:10.1016/j.ejphar.2012.01.046
2 Navari RM, Aapro M. Antiemetic Prophylaxis for Chemotherapy-Induced Nausea and Vomiting. N Engl J Med. 2016;374(14):1356-1367. doi:10.1056/NEJMra1515442
3 Aapro MS. Palonosetron as an anti-emetic and anti-nausea agent in oncology. Ther Clin Risk Manag. 2007;3(6):1009-1020.
About Knight Therapeutics Inc.
Knight Therapeutics Inc., headquartered in Montreal, Canada, is a specialty pharmaceutical company focused on acquiring or in-licensing and commercializing pharmaceutical products for Canada and Latin America. Knight’s Latin American subsidiaries operate under United Medical, Biotoscana Farma and Laboratorio LKM. Knight Therapeutics Inc.'s shares trade on TSX under the symbol GUD. For more information about Knight Therapeutics Inc., please visit the company's web site at or .
Forward-Looking Statements for Knight Therapeutics Inc.
This document contains forward-looking statements for Knight Therapeutics Inc. and its subsidiaries. These forward-looking statements, by their nature, necessarily involve risks and uncertainties that could cause actual results to differ materially from those contemplated by the forward-looking statements. Knight Therapeutics Inc. considers the assumptions on which these forward-looking statements are based to be reasonable at the time they were prepared but cautions the reader that these assumptions regarding future events, many of which are beyond the control of Knight Therapeutics Inc. and its subsidiaries, may ultimately prove to be incorrect. Factors and risks which could cause actual results to differ materially from current expectations are discussed in Knight Therapeutics Inc.'s Annual Report and in Knight Therapeutics Inc.'s Annual Information Form for the year ended December 31, 2023, as filed on Knight Therapeutics Inc. disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information or future events, except as required by law.
About Helsinn
Helsinn is a global pharmaceutical company that builds, manufactures, launches, and commercializes products to improve the quality of life for patients with cancer and chronic disease, with a focus on supportive care, oncology and dermato-oncology. Helsinn, headquartered in Lugano, Switzerland, has direct commercial operations in the U.S. and an extensive network of long-standing trusted partners enabling a commercial presence in more than 90 countries.
Established in 1976, Helsinn is a fourth-generation family-owned company with broad pharmaceutical and technical expertise. Helsinn is proud of its history of operating with great integrity, passion and quality. The company is committed to continuously striving for innovation for its patients and embracing sustainable growth as a core element of its strategic vision.
To learn more about Helsinn, please visit or follow us on and .
For more information:
Helsinn Media Contact:
Sabrina Perucchi
Group Communication Manager
Lugano, Switzerland
Tel: +41 (0) 91 985 21 21
Email:
Investor Contact for Knight Therapeutics Inc.:
Knight Therapeutics Inc.
| Samira Sakhia President & Chief Executive Officer T: 514.484.4483 F: 514.481.4116 Email: Website: | Arvind Utchanah Chief Financial Officer T. +598.2626.2344 Email: Website: |
