Report
Brian Moretta ...
  • Mark Thomas
  • Martin Hall
  • Mike Foster
  • Nigel Hawkins

Hardman & Co Monthly: April 2022

An efficient reporting system has seen all the listed multinational pharmaceutical companies announcing results for 2021, which has given us the opportunity to update our industry statistics and drug database. This report provides the first snapshot of the global and US rankings of the top 20 drug companies for 2021. Comparisons are made with historical data to show how different company strategies have evolved. 2021 was characterised by a strong rebound in performance following the pandemic-affected year in 2020. Much of the growth was driven by antibody-derived drugs and vaccines for treatment and prevention of COVID-19.

► Global market: Hardman & Co estimates that the global prescription drug (Rx) market had growth of 13.7% in 2021, to $1,059bn, up from $931bn in 2020. Underlying growth, excluding COVID-19 vaccines and therapies, was 5.9%, which is consistent with figures given in the annual reports of some drug companies.

► US market: The US market was an important driver of growth, rising 12.2% to $422bn in 2021, from $376bn in 2020, representing 40% of the global market. Despite some continuing limitations caused by COVID-19, the FDA had another productive year, approving 50 new chemical entities (NCEs).

► Biopharmaceuticals: The spend on drugs classified as biopharmaceuticals grew 27.9% to $313bn in 2021, representing 30% of the global market. Drugs derived from antibodies remained an important driver (+20.2% to $187bn), but the performance was boosted dramatically by vaccines (+170% to $90.0bn).

► Best-selling drugs: The global COVID-19 vaccination programme made Comirnaty (Pfizer) the best-selling product in 2021, with sales of $36.8bn. Humira (AbbVie) remains the biggest drug, with ex-factory sales of $20.7bn (+4.3%). The top 10 drugs had global sales of $147.7bn in 2021, representing 13.9% of the entire market. On a cumulative sales basis, there are now eight drugs in the $100bn club.

► R&D investment: The top 20 drug companies by sales reinvested 19.8% of Rx drug sales back into new drug development, spending $133bn out of the total spend of $156bn by the 40 largest companies. The average R&D spend was $6.7bn, ranging from $13.3bn (Roche) to $2.2bn (Vertex).
Underlyings
Advanced Oncotherapy

Advanced Oncotherapy is focused on providing radiotherapy systems for cancer treatment through the use of a proton therapy technology. Co. operates in two business segments: proton therapy and healthcare related properties. The healthcare related property U.K. segment relates to Co.'s property in Folkestone, which is being marketed for sale.

Appreciate Group

Park Group is a provider of prepaid gift cards, multi-retailer gift vouchers and digital rewards services to corporate and consumer markets. Co.'s brands include: Love2shop, a multi-retailer gift voucher and prepaid gift card brand; Park Christmas Savings, which helps families prepare and budget for Christmas in a controlled and careful manner; flexecash®, which issues e-money; Love2shop Business Services, which provides solutions from Co.'s own multi-retailer vouchers and prepaid cards to single store vouchers and cards, gift experiences, holidays and travel; and Evolve, which is a digital rewards platform that provides commercial organizations with a means to reward individuals.

Arbuthnot Banking Group

Arbuthnot Banking Group is primarily involved in banking and financial services. Co. is organized into three main operating segments: Retail banking (associate), which incorporates household cash management, personal lending and banking and insurance services; U.K. Private banking, which incorporates private banking, commercial banking and wealth management; and Group Centre, which is comprised in Co.'s Group Centre management. As of Dec 31 2016, Co.'s total assets were £1.27 billion.

BBGI Global Infrastructure

Bilfinger Berger Global Infrastructure SICAV is a closed-ended, diversified investment company. Co.'s primary investment objective is to invest in a diversified portfolio of operational (or near operational) Public Private Partnership / Private Finance Initiative infrastructure assets or similar assets.

City Of London Investment Group

City of London Investment Group is the holding company for a number of subsidiaries. The principal operating subsidiary is City of London Investment Management Company Limited, which acts as an investment manager on 38 accounts with a total of £3.58 billion under management as at June 30 2017. Co. is an asset management group with an institutional client focus specializing in Emerging Market closed-end fund investments. Co.'s range also include Developed, Frontier and Global Tactical Asset Allocation closed-end fund strategies.

CIZZLE BIOTECHNOLOGY HLDGS PLC

Fidelity Asian Values PLC

Fidelity Asian Values is an investment company. Co. invests in a diversified portfolio of securities and instruments issued by or related to companies listed on the stock markets in the Asian Region excluding Japan. Co. may invest directly in the shares of companies or indirectly through equity related instruments and in debt instruments. Co. may also invest in quoted securities and in other investment funds. Co. invests across a range of sectors, including consumer discretionary, financials, information technology, consumer staples, industrials, health care, utilities, energy, materials, and telecommunication services. Co.'s investment is managed by FIL Investments International.

Fidelity China Special Situations PLC

Fidelity China Special Situations is an investment trust. Co.'s investment objective is to attain long-term capital growth from a managed portfolio made up primarily of securities issued by companies listed in China or Hong Kong and Chinese companies listed elsewhere. Co. may also invest in listed companies with interests in China and Hong Kong.

Fidelity European Values PLC

Fidelity European Values operates as an investment company with a managed portfolio of investments, consisting primarily of continental European securities. Co.'s Portfolio Manager focuses on attaining a total return on Co.'s total assets over the longer term in excess of the Benchmark Index, the FTSE World Europe (ex UK) Index. Co. may utilize derivative instruments, including index-linked notes, futures, contracts for difference, covered call options, put options and other equity-related derivative instruments as a tool to meet its investment objective.

Fidelity Japan Trust

Fidelity Japan Trust is an investment trust company. Co.'s investment objective is to attain long term capital growth from a managed portfolio of securities primarily of small and medium sized Japanese companies listed or traded on Japanese stockmarkets.

Fidelity Special Values PLC

Fidelity Special Values PLC is a United Kingdom-based investment trust. The investment objective of the Company is to achieve long term capital growth predominantly through investment in the United Kingdom listed companies. The Company is engaged in the investments in larger, medium and smaller-sized companies. Its investments have the characteristics, including limited downside risk and unrecognized potential for positive change. The Company focuses on investing up to 20% of the portfolio in listed companies on overseas exchanges. The Company may invest directly in the shares of companies or indirectly through equity-related instruments (such as derivative contracts, warrants or convertible bonds) and in debt instruments. The Company may also invest in unquoted securities. It invests in sectors, including financial services, media, support services, and software and computer services. FIL Investment Services (UK) Limited is the Company's alternative investment fund manager.

ICG Enterprise Trust

ICG Enterprise Trust is an investment trust. Co. is a private equity investment company focused on buyouts in developed markets. Co. invests in private equity funds and also directly in private companies. As of Jan 31 2017, Co.'s total investment portfolio amounted to £594.3 million.

International Biotechnology Trust PLC

International Biotechnology Trust is an independent investment trust company. Co. invests primarily in biotechnology and other life science companies. The portfolio is split between large, mid and small capitalisation companies, primarily quoted on stock exchanges in North America, though investments will also be made in Europe, Asia and Australia. Investments may also be made into unquoted companies and into funds not quoted on a stock exchange, including venture capital funds. Co. has delegated responsibility for day-to-day investment of its assets to the Alternative Investment Fund Manager, SV Health Managers LLP.

Oakley Capital Investments

Palace Capital

Palace Capital is a property investment company that focuses on commercial real estate outside London. Co. invests in refurbishment and capital development programmes within the existing portfolio to unlock capital growth, as well as invests in commercial real estate in the U.K. Co.'s property portfolio includes investment properties located throughout England, predominantly regional investments outside London and comprises a diverse portfolio of commercial buildings.

Pantheon Resources

Pantheon Resources is engaged in the investment in oil and gas exploration and development. Co. operates in the U.K. through its parent undertaking and in the U.S. through subsidiary companies. Co. operates in two reportable segments: USA and Head Office. Non-current assets, income and operating liabilities are attributable to the USA, whilst most of the corporate administration is conducted through Head Office. As of June 30 2017, Co. held 58% working interest in the VOBM#1 & VOBM#2H wells in Polk County. Co. also held 75% working interest in VOBM#4 in Tyler County.

Real Estate Credit Investments

Shield Therapeutics

Shield Therapeutics is a specialty pharmaceutical company focused on the development and commercialization of late stage, hospital-focused pharmaceuticals which address areas of high unmet medical need. Co.'s key products are Feraccru®, commercially available for the treatment of Iron Deficiency Anaemia, and PT20, for the treatment of systemic phosphate accumulation (otherwise known as hyperphosphatemia). Co. has an additional pipeline of three prescription pharmaceutical assets (PT20, PT30 and PT40) with commercial synergies.

Volta Finance (GBP)

Volta Finance is a closed-ended investment company with the objective of investing, among other asset types, in the following main asset classes: Collateralized Loan Obligation, Synthetic Corporate Credit, Cash Corporate Credit and ABS. Co. has appointed AXA Investment Managers Paris S.A., as its Alternative Investment Fund Manager to manage the investments of Co.

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Hardman & Co
Hardman & Co

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Analysts
Brian Moretta

Mark Thomas

Martin Hall

Mike Foster

Nigel Hawkins

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