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Patrik Ling
  • Patrik Ling

SynAct Pharma (No_rec, TP: SEK) - Discontinuing coverage

We have discontinued coverage of SynAct Pharma. Our last published recommendation, target price, and estimates should no longer be relied upon.

Patrik Ling
  • Patrik Ling

SynAct Pharma (No_rec, TP: SEK) - Irregularities in the RESOLVE trial

SynAct Pharma was expected to release data from the 4-week RESOLVE trial in early November. Instead, the company announced it has found multiple irregularities in the data and has therefore initiated a third-party audit of both the RESOLVE and EXPAND trials (as several sites are the same and the same CRO has run the trials). Data should now be released in early 2024 instead. This news has further increased the risk and introduced more uncertainty about the result of the post-hoc analysis from th...

Patrik Ling
  • Patrik Ling

SynAct Pharma (Hold, TP: SEK15.00) - EXPAND trial failed

SynAct Pharma presented disappointing data today (4 September), stating that the EXPAND trial failed to reach a difference between the active arm and placebo. Although the placebo effect might have been greater than expected, the proportion of patients in the active arm that reached ACR20 was also lower than expected. We believe this puts a lot of pressure on the company, as the financial situation is stretched and new capital likely needs to be raised in H2. We have downgraded to HOLD (BUY) and...

Alexander Aukner ... (+6)
  • Alexander Aukner
  • Christoffer Wang Bjørnsen
  • Martin Huseby Karlsen
  • Nicolas McBeath
  • Ole-Andreas Krohn
  • Patrik Ling
Helene Kvilhaug Brøndbo ... (+5)
  • Helene Kvilhaug Brøndbo
  • Jacob Berg Nielsen
  • Ola Trovatn
  • Ole-Andreas Krohn
  • Patrik Ling
Patrik Ling
  • Patrik Ling

SynAct Pharma - Initiation of coverage - Many moving parts

SynAct Pharma is a development-stage biotech company focusing on rheumatoid arthritis (RA), with scope for potential indications in other inflammatory diseases. We believe two positive data readouts in September/October could pave the way for a large out-licensing deal. We initiate coverage with a BUY and SEK170 target price.

Adam Karlsson
  • Adam Karlsson

SynAct Pharma - Q3 report: strong progress but at a cost

No material pipeline updates; timelines intact SEK -41m in operating cash flow; only SEK 51m in cash Share price implications

Adam Karlsson
  • Adam Karlsson

SynAct Pharma - Q2 report

No material updates, timelines intact Next transformative trigger in H2’23 (RA Ph 2 studies) Funding, Nasdaq uplift, and study starts reignites case

Adam Karlsson
  • Adam Karlsson

SynAct Pharma - Q1’22 report

No new material updates SEK 124m issue extends runway to YE’23 Neutral for share

Adam Karlsson
  • Adam Karlsson

SynAct Pharma - First takes on PK data

Completes PK tests of AP1189 tablet Release profile as intended; nausea likely resolved Crucial for long-term case; positive for the share

Adam Karlsson
  • Adam Karlsson

SynAct Pharma - Q4’21 Report

COVID-19 study put on the backburner Main market listing expected by end of H1’22 Implications for the share

Adam Karlsson ... (+2)
  • Adam Karlsson
  • Gonzalo Castanon

SynAct Pharma - Delivering on high expectations

Phase 2a study results more than sufficient Four-week data comparable to JAK & TNF inhibitors We reiterate BUY with a new TP of SEK 170

Adam Karlsson
  • Adam Karlsson

SynAct Pharma - BEGIN Ph 2a study hits the mark

Positive top-line efficacy results Safety profile looks good Proceeding with pre-IND meeting and Ph 2b

Adam Karlsson
  • Adam Karlsson

SynAct Pharma - Getting set for key readout

Rheumatoid arthritis Ph 2a readout in late Nov Nephrotic syndrome study re-designed Share price implications

Adam Karlsson ... (+2)
  • Adam Karlsson
  • Viktor Sundberg

SynAct Pharma - Q2’21 Report

RA readout postponed to Q4’21 Financials Implications for the share

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