Oncopeptides (Buy, TP: SEK335.00) - Updated ANCHOR data at ASH
Updated data from the ANCHOR trial at ASH over the weekend looked strong in our view, especially in combination with daratumumab (the ANCHOR trial looks at combination treatment with melflufen and daratumumab or bortezomib). Patients in the bortezomib arm are still being recruited; hence the data is not as mature as for the combination with daratumumab. We believe the combination data with daratumumab is encouraging for the upcoming phase III LIGHTHOUSE trial, in which melflufen and daratumumab will be combined in a c240-patient trial.Oncopeptides AB is a Sweden-based clinical development pharmaceutical company, which is primarily engaged in the healthcare industry. The Company focuses on research and development of cancer treatment solutions. The Company's product Ygalo is a peptidase potentiated alkylator, a type of cytotoxic drug that is targeted for use in the treatment of multiple myeloma. Ygalo is an alkylating agent that leverages the overrepresentation of peptidase enzymes in cancer cells to rise the concentration of active cancer fighting molecules in myeloma cells. Ygalo is intended for the treatment of patients with late-stage relapsed and refractory multiple myeloma. Ygalo is administered intravenously and is transported into cells where it is cleaved by peptidase enzymes, which impair transport of its active cancer-fighting agents out of the cell at the same time as driving more Ygalo into the cell.
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