Report
Lenny Van Steenhuyse ...
  • Sandra Cauwenberghs

SECTOR NOTE: NASH: State of play

Today, we publish our Life Sciences sector note NASH: State of play. In our overview of the NASH field, we provide insights on what is required from a NASH drug, what targets are explored, compare compounds and map companies involved in NASH clinical development.
Underlyings
Altimmune Inc

Altimmune is a clinical stage immunotherapeutics company focused on the development of products to stimulate immune responses for the prevention and treatment of diseases. The company has two programs using the Respirvec recombinant adenovirus technology: NasoVAX, an intranasally administered recombinant influenza vaccine, uses an adenovector to achieve expression of the influenza antigen in the target cell, thereby stimulating an immune response than influenza vaccines; and NasoShield, an anthrax vaccine designed to provide protection after one intranasal administration. Based on the Densigen platform, HepTcell is an immunotherapy for patients chronically infected with the hepatitis B virus.

Genfit SA

Genfit is a biopharmaceutical company engaged in the discovery and development of drugs and biomarkers in therapeutic areas of high unmet need due to the lack of effective treatments or diagnostic tools and/or due to the increasing number of patients worldwide. Co. concentrates its research and development efforts to participate in the commercialization of treatment solutions and diagnostic tools to fight certain metabolic, inflammatory, autoimmune or fibrotic diseases affecting especially the liver (such as non-alcoholic steatohepatitis or "NASH").

Intercept Pharmaceuticals Inc.

Intercept Pharmaceuticals is a biopharmaceutical company focused on the development and commercialization of therapeutics to treat progressive non-viral liver diseases. The company's marketed product, Ocaliva? (obeticholic acid or OCA), is an farnesoid X receptor agonist approved in the U.S., the European Union and several other jurisdictions for the treatment of primary biliary cholangitis in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA or as monotherapy in adults unable to tolerate UDCA. In addition to, the company is developing OCA for multiple indications, including nonalcoholic steatohepatitis.

Inventiva SA

Inventiva is a clinical stage biotechnology research company delivering therapies in the areas of oncology, fibrosis and rare diseases. The most advanced clinical programs (IVA337 for systemic sclerosis in Non-Alcoholic Steato-Hepatitis and IVA336 for Maroteaux-Lamy syndrome-MPS VI) have demonstrated efficacy in relevant in vivo and in vitro models as well as safety in phase I and phase II clinical trials. Using its in-house drug discovery platform, which covers target validation, screening, chemistry, ADME and pharmacology, Co. is developing an internal oncology and fibrosis discovery pipeline with approaches centered on transcription factors, epigenetics targets and nuclear receptors.

Provider
KBC Securities
KBC Securities

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Analysts
Lenny Van Steenhuyse

Sandra Cauwenberghs

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