Alnylam Preps for Anticipated Approval and Launch; FVE Maintained at $110
We are maintaining our $110 per share fair value estimate for Alnylam following the release of first-quarter earnings and updates to its developmental programs. Model updates to account for the accelerated program timeline of lumasiran in patients with the ultra-rare disease primary hyperoxaluria type 1 (expected launch in 2020 rather than 2021) were offset by higher research and development cost forecasts in line with management’s updated guidance. We are optimistic that Alnylam will gain U.S. ...Alnylam Pharmaceuticals is a commercial-stage biopharmaceutical company developing therapeutics based on RNA interference (RNAi). RNAi is a biological pathway within cells for sequence-specific silencing and regulation of gene expression. The company has two RNAi-based medicines, ONPATTRO? (patisiran) and GIVLAARI? (givosiran). ONPATTRO is approved by the United States Food and Drug Administration (FDA) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and has also been approved in the European Union, Japan, Canada and Switzerland. GIVLAARI is approved by FDA for the treatment of adults with acute hepatic porphyria.
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