Alnylam's Patisiran Supports Positive Moat Trend; Maintaining $110 FVE
We are maintaining our fair value estimate of $110 per share after no-moat Alnylam reported second-quarter results that were in line with our expectations. On July 27, the European Medicines Agency's Committee for Medicinal Products for Human Use adopted a positive opinion of patisiran for hATTR amyloidosis with stage 1 or 2 polyneuropathy, which will be launched as Onpattro later this year. We're anticipating the U.S. Food and Drug Administration to follow suit next week, as the drug is under p...Alnylam Pharmaceuticals is a commercial-stage biopharmaceutical company developing therapeutics based on RNA interference (RNAi). RNAi is a biological pathway within cells for sequence-specific silencing and regulation of gene expression. The company has two RNAi-based medicines, ONPATTRO? (patisiran) and GIVLAARI? (givosiran). ONPATTRO is approved by the United States Food and Drug Administration (FDA) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and has also been approved in the European Union, Japan, Canada and Switzerland. GIVLAARI is approved by FDA for the treatment of adults with acute hepatic porphyria.
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