Following 3Q and Additional Patisiran Data, Increasing Alnylam's FVE to $111
We are increasing our fair value for Alnylam to $111 per share from $92 following third-quarter earnings, primarily to reflect our updated pricing and market share expectations for the company’s amyloidosis candidate patisiran. We believe patisiran’s safety and efficacy profile places it head and shoulders above competitor Ionis’ drug inotersen, despite inotersen’s more convenient subcutaneous dosing. In addition, we adjusted our model to incorporate the pipeline progression of lumasiran (former...Alnylam Pharmaceuticals is a commercial-stage biopharmaceutical company developing therapeutics based on RNA interference (RNAi). RNAi is a biological pathway within cells for sequence-specific silencing and regulation of gene expression. The company has two RNAi-based medicines, ONPATTRO? (patisiran) and GIVLAARI? (givosiran). ONPATTRO is approved by the United States Food and Drug Administration (FDA) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and has also been approved in the European Union, Japan, Canada and Switzerland. GIVLAARI is approved by FDA for the treatment of adults with acute hepatic porphyria.
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