No Surprises in Alnylam's 4Q Results; Onpattro Earns $12 Million in First Full Quarter Since Launch
No-moat Alnylam finished fiscal 2018 with over $12 million in fourth-quarter revenue from its recently launched, first FDA-approved RNAi therapy, Onpattro, as well as about $9 million in revenue from collaborations. While this represents a 13% decline in revenue from last year, we anticipate a significant jump in fiscal 2019 as Onpattro continues to roll out. Operating spend came in within management's previous guidance at about $242 million. Management's guidance for 2019 operating spend came i...Alnylam Pharmaceuticals is a commercial-stage biopharmaceutical company developing therapeutics based on RNA interference (RNAi). RNAi is a biological pathway within cells for sequence-specific silencing and regulation of gene expression. The company has two RNAi-based medicines, ONPATTRO? (patisiran) and GIVLAARI? (givosiran). ONPATTRO is approved by the United States Food and Drug Administration (FDA) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults and has also been approved in the European Union, Japan, Canada and Switzerland. GIVLAARI is approved by FDA for the treatment of adults with acute hepatic porphyria.
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