Exelixis' Pivotal Liver Cancer Results Don't Knock It Out of the Ballpark; $28.50 FVE Unchanged
Exelixis has posted full results for its pivotal Celestial trial evaluating cabozantinib in second-line hepatocellular carcinoma, or HCC, a type of liver cancer. While we think approval in this indication with high unmet need is likely, cabozantinib’s results didn’t hit it out of the ballpark. Recently approved second-line therapies, Stivarga and Opdivo, showed better overall survival rates, although Stivarga has a black-box label for liver toxicity and Opdivo was granted accelerated approval an...Exelixis is an oncology-focused biotechnology company that involved in the discovery, development and commercialization of new medicines for cancers. The company's marketd products are: CABOMETYX? (cabozantinib) tablets for renal cell carcinoma and previously treated hepatocellular carcinoma; and COMETRIQ? (cabozantinib) capsules for progressive, metastatic medullary thyroid cancer. The company's products resulting from its discovery efforts are: COTELLIC? (cobimetinib), an inhibitor of MEK approved as part of a combination regimen to treat melanoma; and MINNEBRO? (esaxerenone), an oral, non-steroidal, selective blocker of the mineralocorticoid receptor approved for the treatment of hypertension in Japan.
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