Advance Auto Parts is an automotive aftermarket parts provider in North America, serving both professional installers (Professional), and do-it-yourself (DIY), customers as well as independently owned operators. The company's stores and branches provide a range selection of brand name, original equipment manufacturer and private label automotive replacement parts, accessories, batteries and maintenance items for domestic and imported cars, vans, sport utility vehicles and light and heavy duty trucks. Through its integrated operating approach, the company serves its Professional and DIY customers through a variety of channels ranging from brick and mortar store locations to self-service e-commerce sites.

Affiliated Managers Group is a global asset management company with equity investments in boutique investment management firms (Affiliates). The company provides centralized capabilities to its Affiliates, including strategy, marketing and distribution, and product development. Through its Affiliates, the company provides strategies designed to assist institutional, retail and clients worldwide in achieving their investment objectives. The company provides boutique investment management services to retail investors through advisory and sub-advisory services to return-oriented mutual funds, Undertakings for the Collective Investment of Transferable Securities, collective investment trusts and other retail products.

Agios Pharmaceuticals is a biopharmaceutical company focused on areas of hematologic malignancies, solid tumors and rare genetic diseases. The company's product, TIBSOVO? (ivosidenib) is for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (R/R AML) with a susceptible isocitrate dehydrogenase (IDH) 1 mutation. The company's other product is IDHIFA? (enasidenib) for patients with R/R AML and an IDH2 mutation. The company's pre-commercial clinical cancer product candidates include: vorasidenib, a brain-penetrant pan-IDH mutant inhibitor; and AG-270, an orally available selective inhibitor of methionine adenosyltransferase 2a.

Alcoa is a vertically integrated aluminum company comprised of bauxite mining, alumina refining, aluminum production (smelting, casting, and rolling), and energy generation. Through direct and indirect ownership, the company has 30 operating locations in nine countries around the world, situated primarily in Australia, Brazil, Canada, Iceland, Norway, Spain, and United States.

American Eagle Outfitters is a multi-brand retailer. The company operates retail stores and online at www.ae.com and www.aerie.com. The company provides a range of apparel and accessories for men and women under the American Eagle Outfitters brand, and intimates, apparel and personal care products for women under the Aerie brand. The company operates stores in the U.S., Canada, Mexico, Hong Kong, and China. The company also has license agreements with third-parties to operate American Eagle Outfitters and Aerie stores throughout Asia, Europe, India, Latin America and the Middle East. The company also operates two other brands, Tailgate, a vintage, sports-inspired apparel brand, and Todd Snyder New York, a menswear brand.

AnaptysBio is a clinical stage biotechnology company developing antibody product candidates. Etokimab, the company's anti-IL-33 antibody drug candidate, inhibits the activity of the interleukin-33 cytokine that is applicable to the treatment of atopic inflammatory disorders, such as moderate-to-severe atopic dermatitis, eosinophilic asthma, chronic rhinosinusitis with nasal polyps, and potentially other allergic conditions. ANB019 inhibits the interleukin-36 receptor, for the treatment of rare inflammatory diseases including generalized pustular psoriasis and palmoplantar pustulosis. The company's wholly-owned pipeline includes anti-inflammatory checkpoint receptor modulator antibodies.

ArcBest is a holding company. Through its subsidiaries, the company provides a suite of freight transportation services and integrated logistics solutions. The company's operations are conducted through three reportable operating segments: Asset-Based, ArcBest, and FleetNet. The company's Asset-Based segment provides less-than-truckload services through its subsidiary, ABF Freight System, Inc., and certain other subsidiaries' motor carrier operations. The ArcBest and FleetNet reportable segments, combined, represent the company's Asset-Light operations, which provide customers end-to-end logistics solutions, designed to satisfy the supply chain and shipping requirements they encounter.

Astronics is a provider of technologies to the aerospace, defense and electronics industries. The company has two reportable segments, Aerospace and Test Systems. The company's Aerospace segment designs and manufactures products for the global aerospace industry. Product lines include lighting and safety systems, electrical power generation, distribution and motions systems, aircraft structures, avionics products, systems certification, and other products. The company's Test Systems segment designs, develops, manufactures and maintains automated test systems that support the aerospace, communications and weapons test systems as well as training and simulation devices for both commercial and military applications.

At Home Group is a holding company. Through its subsidiaries, the company is a home decor superstore. The company's product mix includes home furnishings, which consists of accent furniture, furniture, mirrors, patio cushions, rugs and wall art. Accent decor consists of artificial flowers and trees, bath, bedding, candles, garden and outdoor decor, holiday accessories, home organization, pillows, pottery, vases and window treatments. The company operates its stores primarily in the South Central, Southeastern, Mid-Atlantic and Midwestern regions of the U.S. In addition, the company operates a distribution center and warehouse premises in Texas, which services its stores, and a second distribution center in Pennsylvania.

Box provides a cloud content management platform that enables organizations to manage their content. With the company's Software-as-a-Service cloud content management platform, users can collaborate on content internally and with external parties, automate content-driven business processes, develop applications, and implement data protection, security and compliance features to comply with legal and regulatory requirements, internal policies and industry standards and regulations. The company's platform enables a set of business use cases across an enterprise and various file formats and media types. The company also provides offerings that address business needs via technology, services and marketing programs.

Cambridge Bancorp is a bank holding company. Through its bank subsidiary, Cambridge Trust Company (the Bank), the company focuses on wealth management, the commercial banking business and private banking for clients including residential lending and personal banking. The Bank is engaged primarily in the business of accepting deposits from the public and investing those deposits. The Bank invests those funds in various types of loans, including residential and commercial real estate, and a variety of commercial and consumer loans. The Bank also invests its deposits and borrowed funds in investment securities.

Century Aluminum is a holding company. Through its subsidiaries, the company produces primary aluminum and operates aluminum reduction facilities in the U.S. and Iceland. The company's principal subsidiaries are: Century Kentucky, Inc., which operates a primary aluminum reduction facility in Hawesville, KY; Nordural ehf, which operates a primary aluminum reduction facility in Grundartangi, Iceland; Century Aluminum Sebree LLC, which operates a primary aluminum reduction facility in Robards, KY; Century Aluminum of South Carolina, which operates a primary aluminum reduction facility in Goose Creek, SC; and Nordural Helguvik ehf, which owns a greenfield primary aluminum project in Helguvik, Iceland.

Chemours is a provider of performance chemicals. The company has three reportable segments: Fluoroproducts, Chemical Solutions, and Titanium Technologies. The company's Fluoroproducts segment is a provider of fluoroproducts, including refrigerants and industrial fluoropolymer resins. The company's Chemical Solutions segment is a North American provider of industrial chemicals used in gold production, industrial, and consumer applications. The company's Titanium Technologies segment is a provider of titanium dioxide pigment, a white pigment used to deliver whiteness, brightness, opacity, and protection in a variety of applications.

Citigroup is a financial services holding company whose businesses provide consumers, corporations, governments and institutions with a range of financial products and services, including consumer banking and credit, corporate and investment banking, securities brokerage, trade and securities services and wealth management. The company operates via two primary business segments: Global Consumer Banking, which provides banking services to retail customers through retail banking, Citi-branded cards and Citi retail services; and Institutional Clients Group, which includes banking and markets and securities services.

Citizens Financial Group is a bank holding company. The company's principal business activity is banking, conducted through its banking subsidiary Citizens Bank, National Association. The company's operating segments are: Consumer Banking and Commercial Banking. In Consumer Banking, the company provides mobile and online banking, a 24/7 customer contact center and automated teller machines. Consumer Banking products and services include a range of banking, lending, savings, wealth management and small business offerings. In Commercial Banking, the company provides corporate, institutional and not-for-profit clients a range of wholesale banking products and services including lending and deposits, and capital markets.

CorMedix is a biopharmaceutical company focused on developing and commercializing therapeutic products for the prevention and treatment of infectious and inflammatory diseases. The company's primary focus is on the development of its primary product candidate, Neutrolin?, for potential commercialization in the United States and other main markets. The company has in-licensed the worldwide rights to develop and commercialize Neutrolin. Neutrolin is an anti-infective solution for the reduction and prevention of catheter-related infections and thrombosis in patients requiring central venous catheters in clinical settings such as dialysis, critical/intensive care, and oncology.

Cyclerion Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of sGC pharmacology to discover, develop and commercialize breakthrough treatments for serious and orphan diseases. The company's focus is enabling the full therapeutic potential of next-generation sGC stimulators. sGC stimulators are small molecules that act synergistically with nitric oxide on sGC to boost production of cyclic guanosine monophosphate, or cGMP. cGMP is a key second messenger that, when produced by sGC, regulates diverse and critical biological functions throughout the body including blood flow and vascular dynamics, inflammatory and fibrotic processes, metabolism and neuronal function.

Daseke is a provider of transportation and logistics solutions focused on flatbed and freight in North America. The company delivers transportation and logistics solutions to customers across the continental United States, Canada and Mexico. The company's reportable segments are: Flatbed Solutions and Specialized Solutions. The Flatbed Solutions segment focuses on delivering transportation and logistics solutions that principally require the use of flatbed and retractable-sided transportation equipment, and the Specialized Solutions segment focuses on delivering transportation and logistics solutions that principally include heavy haul, customized, over-dimensional, commercial glass and cargo solutions.

Dell Technologies is a holding company. Through its subsidiaries, the company designs, develops, manufactures, markets, sells, and supports a range of products and services. The company's reportable segments are: Infrastructure Solutions Group, which includes servers, networking, and storage, as well as services and third-party software and peripherals; Client Solutions Group, which includes desktops, thin client products, and notebooks, as well as services and third-party software and peripherals; and VMware, which provides compute, cloud management, networking and security, storage and availability, and other end-user computing offerings.

Dycom Industries is a provider of specialty contracting services. The company supplies telecommunications providers with a portfolio of specialty services, including program management; planning; engineering and design; aerial, underground, and wireless construction; maintenance; and fulfillment services for telecommunications providers. Additionally, the company provides underground facility locating services for various utilities, including telecommunications providers, and other construction and maintenance services for electric and gas utilities. The company supplies the labor, tools, and equipment necessary to provide these services to its customers.

Dynavax Technologies is a biopharmaceutical company focused on utilizing the power of the body's innate and adaptive immune responses through toll-like receptor (TLR) stimulation. The company's commercial product, HEPLISAV-B? (Hepatitis B Vaccine (Recombinant), Adjuvanted), is approved for prevention of infection caused by various known subtypes of hepatitis B virus in adults age 18 years and older. The company's development efforts are focused on stimulating the innate immune response to treat cancer in combination with other immunomodulatory agents. The company's pipeline of product candidates includes: SD-101, which is its cancer immunotherapy candidate; and DV281, which is an investigational TLR9 agonist.

Editas Medicine is a clinical stage genome editing company focused on developing genomic medicines to treat a range of serious diseases. The company has developed a proprietary genome editing platform based on clustered, regularly interspaced, short palindromic repeats (CRISPR) technology. The company is developing both in vivo CRISPR medicines, in which the medicine is injected or infused into the patient to edit the cells inside their body, and engineered cell medicines, in which cells are edited with the company's technology and then administered to the patient. In ocular diseases, the company's program is designed to address a specific genetic form of retinal degeneration called Leber congenital amaurosis 10.

Endurance International Group Holdings provides cloud-based platform solutions for small and medium-sized businesses. The company's segments are: Web Presence, which consists of web hosting brands, such as Bluehost and HostGator, as well as related products such as domain names, website security, website design tools and services, and e-commerce products; Email Marketing, which consists of Constant Contact email marketing tools and related products, its Constant Contact-branded website builder tool and its Ecomdash inventory management and marketplace listing solution; and Domain, which consists of domain-focused brands such as Domain.com, ResellerClub and LogicBoxes and certain web hosting brands.

EZCORP is a provider of pawn loans in the United States and Latin America. The company's business consists of the following three reportable segments: United States Pawn, which includes its EZPAWN, Value Pawn and Jewelry and other pawn operations in the United States; Latin America Pawn, which includes its Empeno Facil and other branded pawn operations in Mexico, as well as the company's GuatePrenda and MaxiEfectivo pawn operations in Guatemala, El Salvador, Honduras and Peru; and Other International, which includes primarily the company's CASHMAX financial services operations in Canada and its equity interest in the net income of Cash Converters International.

FB Financial is a bank holding company. Through its bank subsidiary, FirstBank (the Bank), the company is engaged in providing a suite of commercial and consumer banking services to clients. The company's commercial lending products include working capital lines of credit, equipment loans, owner-occupied and non-owner-occupied real estate construction loans, mini-perm real estate term loans, and cash flow loans to a mix of clients, including small and medium sized businesses. The company's consumer lending products include first and second residential mortgage loans, home equity lines of credit and consumer installment loans to purchase cars, boats and other recreational vehicles.

Fifth Third Bancorp is a bank holding company. Through its subsidiaries, the company provides financial products and services to the commercial, financial, retail, governmental, educational, energy and healthcare sectors. The company's segments are: Commercial Banking, which provides credit intermediation, cash management and financial services; Branch Banking, which provides a range of deposit and loan products to individuals and small businesses; Consumer Lending, which includes the company's residential mortgage, automobile and other indirect lending activities; and Wealth and Asset Management, which provides a range of investment alternatives for individuals, companies and not-for-profit organizations.

First Solar is a provider of photovoltaic (PV) solar energy solutions. The company designs, manufactures and sells PV solar modules with a thin film semiconductor technology, and also develops and sells PV solar power systems that mainly use the modules it manufactures. The company also provides operations and maintenance (O&M) services to system owners. The company's modules segment involves the design, manufacture and sale of cadmium telluride solar modules, which convert sunlight into electricity. The company's second segment is its systems segment, through which it provides power plant solutions, which include project development, engineering, procurement, and construction services and O&M services.

Five Prime Therapeutics is a clinical-stage biotechnology company focused on discovering and developing protein therapeutics. The company's key product candidates are: FPA150, which is a CD8 T cell checkpoint inhibitor antibody that targets B7-H4 that it is studying in a clinical trial in multiple cancers; FPT155, which is a soluble CD80 fusion protein that enhances co-stimulation of T cells through CD28 that the company is studying in a clinical trial in multiple cancers; and Cabiralizumab (FPA008) is an antibody that the company and its partner Bristol-Myers Squibb Company, or BMS, are studying in clinical trials in multiple cancers in combination with BMS's PD-1 immune checkpoint inhibitor, Opdivo? (nivolumab).

Fluor is a holding company. Through its subsidiaries, the company provides engineering, procurement, construction, fabrication and modularization, operations, maintenance and asset integrity, as well as project management services. The company serves a set of industries including oil and gas, chemicals and petrochemicals, mining and metals, transportation, power, life sciences and manufacturing. The company is also a service provider to the U.S. federal government and governments abroad; and it performs operations, maintenance and asset integrity activities for industrial clients. The company has four segments: Energy & Chemicals; Mining, Industrial, Infrastructure & Power; Diversified Services; and Government.

Focus Financial Partners is a partnership of independent, fiduciary wealth management firms operating in the registered investment advisor industry, with a footprint of several partner firms primarily in the United States. The company's partner firms primarily service high net worth individuals and families by providing wealth management services. The company's wealth management services include investment advice, financial and tax planning, consulting, tax return preparation, family office services, and other services. The company also provides recordkeeping and administration services.

Fox Factory Holding is a holding company. Through its subsidiaries, the company is a designer, manufacturer and marketer of products and systems used on bicycles, side-by-side vehicles, on-road vehicles with and without off-road capabilities, off-road vehicles and trucks, all-terrain vehicles, snowmobiles, specialty vehicles and applications, motorcycles, and commercial trucks. In its powered vehicle product categories, the company provides products under the FOX, BDS Suspension, Zone Offroad, JKS Manufacturing, RT Pro UTV, 4x4 Posi-Lok, and Tuscany brands. The company's bike product offerings are used on a range of mountain bikes and road bikes under the FOX, Race Face, Easton Cycling and Marzocchi brands.

Freeport-McMoRan is a holding company. Through its subsidiaries, the company is a mining company. The company operates assets with proven and probable reserves of copper, gold and molybdenum, and the company is a publicly traded copper producer. The company's portfolio of assets includes the Grasberg minerals district in Indonesia, copper and gold deposits; and mining operations in North America and South America, including the Morenci minerals district in Arizona and the Cerro Verde operation in Peru. The company has organized its mining operations into four primary divisions: North America copper mines, South America mining, Indonesia mining and Molybdenum mines.

G-III Apparel Group designs, sources and markets a range of apparel, including outerwear, dresses, sportswear, swimwear, women's suits and women's performance wear, women's handbags, footwear, small leather goods, cold weather accessories and luggage. The company has two segments: wholesale operations, which includes sales of products under brands licensed by the company from third parties and sales of products under its own brands and private label brands, and sales related to the Vilebrequin business; and retail operations, which consists of the company's Wilsons Leather, G.H. Bass and DKNY stores operated as outlet stores, and a limited number of Calvin Klein Performance and Karl Lagerfeld Paris stores.

The Gap is an apparel retail company. The company provides apparel, accessories, and personal care products for men, women, and children under the Old Navy, Gap, Banana Republic, Athleta, Intermix, and Hill City brands. The company has stores in the U.S., Canada, the U.K., France, Ireland, Japan, Italy, China, Hong Kong, Taiwan, and Mexico, and has franchise agreements with unaffiliated franchisees to operate Old Navy, Gap, and Banana Republic stores throughout Asia, Europe, Latin America, the Middle East, and Africa. Under these agreements, third parties operate stores that sell apparel and related products under the company's brand names.

Green Dot is a bank holding company. Through its subsidiaries, the company provides a collection of banking and financial services products marketed directly to consumers through its banking platforms. The company's reportable segments include: Account Services, which provides several deposit account programs that can be acquired through its omni-channel branchless distribution platform, including consumer and small business checking account products, network-branded reloadable prepaid debit cards and secured credit programs; and Processing and Settlement Services, which provides several products and services that engage in facilitating the movement of funds on behalf of consumers and businesses.

Health Catalyst is a provider of data and analytics technology and services to healthcare organizations. The company designs, develops, and delivers healthcare software solutons for hospitals to manage operational, financial, clinical, and research data. The company serves customers in the State of Utah.

Invitae is engaged in genetic testing services that support patient care throughout life's journey from inherited disease diagnosis, to family planning, to health screening with a network of patients, healthcare providers, biopharma and advocacy partners. The company's tests include genes associated with hereditary cancer, neurological disorders, cardiovascular disorders, pediatric disorders, metabolic disorders and other hereditary conditions. In addition, the company's services also include screening and testing in reproductive health, including preimplantation and carrier screening for inherited disorders, prenatal diagnosis, miscarriage analysis and pediatric developmental disorders.

Marine Products manufactures fiberglass motorized boats distributed and marketed through its independent dealer network. The company' product offerings include its subsidiaries, Chaparral Boats, Inc. (Chaparral) sterndrive, outboard and jet pleasure boats and Robalo Boats, LLC (Robalo) outboard sport fishing boats. The company designs, manufactures and sells recreational fiberglass powerboats in the sportboat, sport fishing and jet boat markets. The Chaparral product line includes: SSi Sport Boats, SSX Sport Boats, Surf Series, SunCoast Bowriders, OSX Sport Boats, and Vortex Jet Boats. The Robalo product line includes: Center Consoles, Cayman Bay Boats, and Dual Consoles.

Nektar Therapeutics is a research-based biopharmaceutical company. The company's proprietary drugs and drug candidates that have either received regulatory approval or are being developed by the company or in collaboration with other pharmaceutical companies or independent investigators include: ONZEALD?, a topoisomerase I inhibitor targeted for advanced metastatic breast cancer in patients with brain metastases; NKTR-181, an orally-available mu-opioid analgesic molecule for moderate to severe chronic pain; NKTR-214, a CD122-biased immune-stimulatory cytokine targeted for oncology; NKTR-358 for autoimmune disease; NKTR-262 targeted for solid tumors; and NKTR-255 targeted for immuno-oncology.

New Relic is a provider of an integrated, multi-tenant, cloud-based instrumentation and analytics platform that enables users to collect, store and analyze amounts of data in real time. The company's products include: New Relic Application Performance Management, which provides visibility into the performance and usage of server-based applications; New Relic Mobile, which provides code-level visibility into the performance and health of mobile applications running on the iOS and Android mobile operating systems; New Relic Browser; New Relic Synthetics; New Relic Infrastructure; and New Relic Insights.

Nu Skin Enterprises develops and distributes a line of beauty and wellness solutions. The company's primary product categories are personal care products and wellness products. The company develops and distributes products in these two categories under its Nu Skin and Pharmanex brands, respectively. The company's personal care products include its skin care devices. The company's skin care devices and related consumables are ageLOC Spa systems and its ageLOC LumiSpa skin treatment and cleansing device. The company's wellness products line includes its LifePak nutritional supplements, ageLOC Youth nutritional supplements and its ageLOC TR90 weight management and body shaping system.

Occidental Petroleum has three reporting segments: oil and gas, which explores for, develops and produces oil and condensate, natural gas liquids (NGL) and natural gas; chemical, which mainly manufactures and markets basic chemicals (chlorine, caustic soda, chlorinated organics, potassium chemicals, ethylene dichloride, chlorinated isocyanurates, sodium silicates and calcium chloride) and vinyls (vinyl chloride monomer, polyvinyl chloride and ethylene); and marketing and midstream, which purchases, markets, gathers, processes, transports and stores oil, condensate, NGL, natural gas, carbon dioxide and power.

OptiNose is pharmaceutical company focused on the development and commercialization of products for patients treated by ear, nose and throat and allergy specialists. The company's first commercial product, XHANCE? (fluticasone propionate) nasal spray, 93 mcg, is a therapeutic utilizing its key Optinose Exhalation Delivery System (EDS) that delivers a topically-acting corticosteroid for the treatment of chronic rhinosinusitis with nasal polyps and, if approved, chronic rhinosinusitis without nasal polyps (chronic sinusitis). The company's other candidate includes OPN-300, which combines an Optinose EDS with oxytocin to target two orphan indications: Prader-Willi syndrome and autism spectrum disorder.

Rayonier Advanced Materials is a manufacturer of cellulose products, lumber, and pulp & paper products. The company's operating segments are: High Purity Cellulose, which manufactures and markets cellulose, which is sold as either cellulose specialties or commodity products that is primarily used in dissolving chemical applications; Forest Products, which the lumber, primarily spruce, pine, or fir, is used in the construction of residential and multi-family homes, light industrial and commercial facilities, and the home repair and remodel markets; Pulp, which manufactures and markets pulp products; and Paper, which manufactures and markets paper products consisting of paperboard and newsprint.

Resideo Technologies is a global provider of comfort, residential thermal solutions and security solutions primarily in residential environments. The company's products consist of solutions in Comfort, Residential Thermal Solutions and Security categories and include temperature and humidity control, thermal, water and air solutions and remote patient monitoring software solutions as well as security panels, sensors, peripherals, wire and cable, communications devices, video cameras, awareness solutions, cloud infrastructure, installation and maintenance tools and related software. The company's ADI Global Distribution business is the wholesale distributor of security and low voltage electronic products.

Shoe Carnival is a family footwear retailers. The company provides customers a a range of dress, casual and athletic footwear for men, women and children with an emphasis on national name brands. The company operates stores in the states and Puerto Rico and provides online shopping at www.shoecarnival.com. The company's stores carry complementary accessories such as socks, belts, shoe care items, handbags, sport bags, backpacks, scarves and wallets, while its e-commerce site provides certain handbags, sport bags and backpacks. Women's, men's and children's non-athletic footwear categories are further divided into dress, casual, sport, sandals and boots.

Surmodics is a provider of medical device and in vitro diagnostic technologies to the healthcare industry. The company's segments are comprised of: Medical Device, which provides surface coatings and device drug-delivery technologies that impart lubricity, prohealing or biocompatibility characteristics, as well as drug delivery capabilities; and In Vitro Diagnostics (IVD), in which the company manufactures and sells components for IVD immunoassay and molecular tests and the company sells these components to the diagnostic, biomedical research, and life science markets. The company also provides colorimetric and chemiluminescent substrates to the IVD market under its BioFX? trademark.

U.S. Bancorp is a multi-state financial services holding company. Through its subsidiaries, the company provides a range of financial services, including lending and depository services, cash management, capital markets, and trust and investment management services. The company also engages in credit card services, merchant and ATM processing, mortgage banking, insurance, brokerage and leasing. The company's subsidiary, U.S. Bank National Association, is engaged in the general banking business, principally in domestic markets. The company's bank and trust subsidiaries provide a range of asset management and fiduciary services for individuals, estates, foundations, business corporations and charitable organizations.

Unity Biotechnology is a biotechnology company engaged in researching and developing therapeutics to extend healthspan by slowing, halting or reversing diseases of aging. UBX0101 is the company's main drug candidate for musculoskeletal disease with an initial focus on osteoarthritis of the knee. It is a small molecule inhibitor of the MDM2/p53 interaction. In addition, UBX1325 and UBX1967 are the company's main drug candidates for age-related diseases of the eye, including age-related macular degeneration, diabetic macular edema and diabetic retinopathy. These drug candidates are both senolytic small molecule inhibitor of specific members of the Bcl-2 family of apoptosis regulatory proteins.

UPWORK operates an online talent marketplace, which enables businesses to find and work with independent personnel. Freelancers on the company's platform include independent personnel and agencies of varying sizes. The company's marketplace offerings include Upwork Basic, Upwork Plus, Upwork Business, Upwork Enterprise, and Upwork Payroll. The company,'s Upwork Basic offering provides clients with access to freelance talent with verified work history on its platform and client feedback, the ability to match with the freelancers, and built-in collaboration features. The company's Upwork Plus provides all the product features of Upwork Basic, as well as access to personalized assistance, whether strategic or job-specific.