Medistim (Hold, TP: NOK190.00) - Sales in Americas weaken

Revenues grew 3.5% YOY in Q1 (currency-neutral total sales grew 2.2%), below our estimate c6%. The EBIT margin of 24% was almost back to normal and in our view shows the low margin in Q4 2023 (16.4%) should be seen as a one-off. However, we remain concerned about revenue growth, especially in the Americas, after the fifth consecutive quarter of declining currency-neutral sales. Thus, while we reiterate our HOLD, we have lowered our 2024–2026e sales by c3–8% and cut our target price to NOK190 (21...

Alvotech (Buy, TP: USD21.00) - Strong fiscal 2024–2025 guidance

Alvotech reported fiscal Q4 2023 earnings and hosted a CMD late last week. These were broadly in line with our expectations, but also rather a non-event given the late reporting and developments that have taken place in Q1 (approval of AVT02 in the US), and approval of AVT04 in the US, expected in April. Guidance for 2024 (and 2025) was stronger than we had expected. Overall, we reiterate our BUY and have raised our target price to USD21 (19).

Medistim (Hold, TP: NOK210.00) - Decreased EBIT margin

Revenues were down in all regions in Q4, with currency-neutral total sales down c13.7% YOY. Due to various strategic initiatives, the EBIT margin was unusually low in the quarter, but we expect it to gradually come back to ‘normal’ levels of 25–30%. However, we have lowered our sales estimates, downgraded to HOLD and lowered our target price to NOK210 (260).

Alvotech (Buy, TP: USD19.00) - Simlandi approved in the US

Over the weekend, Alvotech announced that the FDA has finally approved Simlandi (AVT02) for sale in the US after its latest inspection of the facility in Reykjavik. We consider this a key event, as Simlandi will be the first biosimilar to Humira in the US, which for the high-concentration formulation (c88% of Humira use is high-concentration in the US) is citric-free and has approved interchangeability. We reiterate our BUY and have raised our target price to USD19 (11).

Alvotech (Buy, TP: USD11.00) - Key FDA inspection in January 2024

Alvotech reported slightly lower Q3 revenues than we expected, and the operating costs were also higher than we forecast. However, we believe the most important event in the coming months will be the FDA inspection of the manufacturing facility in Iceland, which if successful, would probably be the last item needed to receive approval for AVT02 (Humira biosimilar) and AVT04 (Stelara biosimilar) in the US. We reiterate our BUY but have reduced our target price to USD11 (11.5) on our forecast adju...

Medistim (Buy, TP: NOK260.00) - Currency tailwind

Medistim’s Q3 sales growth of 6.5% YOY was helped by favourable currency. Currency-neutral sales growth was negative, especially in the Americas, causing us to cut our sales estimates (especially in this region). Following adjustments of our sales forecasts, we have lowered our target price to NOK260 (290), but reiterate our BUY.

Northern Lights

Alvotech (Buy, TP: USD11.50) - Product sales on the weak side

Alvotech reported lower than expected Q2 product sales of AVT02, but indicated we should see a rebound in the coming quarters. As for the ongoing registration process for AVT02 in the US, the company recently resubmitted its BLA and a new BsUFA date should be in early 2024. Moreover, the company is ready for a re-inspection of its manufacturing facility in Reykjavik. We reiterate our BUY but have cut our target price to USD11.5 (13).

Medistim (Buy, TP: NOK290.00) - Growth boosted by currency effects

Medistim reported Q2 sales and EBIT above our estimates, but the company benefited from favourable currency effects. Despite the temporarily increased expenses related to the establishment of direct-sales operations, the EBIT margin remained above 30%. We reiterate our BUY and NOK290 target price.

Northern Lights

Alvotech (Buy, TP: USD13.00) - Another CRL for AVT02 in the US

Alvotech reported late last week that it has received another CRL for the second BLA regarding AVT02 (Humira high-concentration biosimilar with interchangeability). In our view, this is bad news, as a re-inspection of the Reykjavik facility seems necessary and a re-filing of the BLA (triggering a 6-month review period) should lead to an approval in early 2024 (the original plan was to launch in early July this year). The delayed launch will trigger a need for additional cash, and the company hig...

Northern Lights

Alvotech (Buy, TP: USD13.00) - Uncertainty for AVT02 remains

Alvotech reported somewhat lower Q1 earnings than we expected. However, 2023 is set to be back-end loaded, especially on the milestone revenues. There were no timelines presented on the CRL for AVT02 in the US; thus, the uncertainty remains on when the product could be approved and launched. However, Alvotech revealed two new projects in the pipeline, biosimilars for pembrolizumab and vedolizumab. We reiterate our BUY but have cut our target price to USD13 (15).

Medistim ASA: 1 director

A director at Medistim ASA sold 37,719 shares at 265.000NOK and the significance rating of the trade was 83/100. Is that information sufficient for you to make an investment decision? This report gives details of those trades and adds context and analysis to them such that you can judge whether these trading decisions are ones worth following. Included in the report is a detailed share price chart which plots discretionary trades by all the company's directors over the last two years clearly s...

Northern Lights

Medistim (Buy, TP: NOK290.00) - Growth continues in 2023

While sales benefited from favourable currency effects, Medistim reported another strong quarter, with Q1 sales above our estimate. A weaker EBIT margin can partly be attributed to the company building direct sales forces in China and Canada and thus executing on its strategy. It now has direct sales representation in the largest markets in North America (US), Europe (Germany) and Asia (China). We reiterate our BUY and NOK290 target price.

Northern Lights

Alvotech (Buy, TP: USD15.00) - CRL for AVT02 in the US

Alvotech said on Friday it had received a CRL for the approval application for AVT02 (adalimumab biosimilar) after the FDA’s facility inspection in Reykjavik. This is clearly negative news and introduces high uncertainty in the stock until the manufacturing issues have been resolved. The CRL included no issues relating to the clinical data for AVT02, which was good. Given the CRL and risk of a delayed launch of AVT02 in the US, we have cut our target price to USD15 (19) but reiterate our BUY.

Medistim (Buy, TP: NOK290.00) - Q4 sets new quarterly sales record

Q4 revenue of cNOK141.8m was a new quarterly record, reflecting broad-based geographical growth. Medistim also enjoyed a currency tailwind, but even excluding this we believe it again demonstrated strength, and we reiterate our BUY and NOK290 target price.

Northern Lights