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Novo Nordisk AS: 1 director
A director at Novo Nordisk AS sold 40,000 shares at 450.528DKK and the significance rating of the trade was 100/100. Is that information sufficient for you to make an investment decision? This report gives details of those trades and adds context and analysis to them such that you can judge whether these trading decisions are ones worth following. Included in the report is a detailed share price chart which plots discretionary trades by all the company's directors over the last two years clear...
- Rune Majlund Dahl
Zealand Pharma (Buy, TP: DKK950.00) - Dapiglutide likely next catalyst
Q1 revenue missed expectations on lower reimbursement revenue, while operating profit was a beat, as opex was below our forecast and consensus. The 2025 guidance was maintained for opex of DKK2,000m–2,500m. We believe the next potential share-price catalyst is the top-line results from the phase Ib dapiglutide trial in Q2e. We reiterate our BUY, but have cut our target price to DKK950 (1,000).
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK900.00) - Accelerated Wegovy roll-out ahead
Q1 LCY figures beat our forecasts, while the 2025 guidance was cut to 13–21% LCY sales growth YOY and 16–24% LCY operating profit growth YOY due to weaker GLP-1 sales. We have lowered our rebate for US Ozempic but maintain our 52% Wegovy rebate (in line with the Q1 rebate when adjusting for de-stocking). We reiterate our BUY and DKK900 target price.
e-therapeutics Presents New Data Supporting ETX‑312 as a Differentiate...
e-therapeutics Presents New Data Supporting ETX‑312 as a Differentiated and Disease-Modifying Near-Clinic Treatment for MASH LONDON, May 07, 2025 (GLOBE NEWSWIRE) -- e-therapeutics plc, a company integrating computational power and biological data to discover life-transforming RNAi medicines, today announced it will present new preclinical results on its GalOmic small‑interfering RNA (siRNA) candidate ETX‑312 for the treatment of metabolic dysfunction‑associated steatohepatitis (MASH) at the European Association for the Study of the Liver (EASL) Congress, 7th-10th May 2025. In the ...
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK900.00) - Underlying soft GLP-1 sales
We forecast a soft Q1, with 17.3% LCY sales growth and 13.8% LCY operating profit growth due to subdued prescriptions. While we estimate Ozempic sales c0.5% below consensus, we are c1.2% above for Wegovy, as we include DKK1bn in sales related to Wegovy US inventories. We see likely relief from potential unchanged 2025 LCY guidance, supported by improved Wegovy supply and fading pressure from compounders. We reiterate our BUY and DKK900 target price.
- Rune Majlund Dahl
Zealand Pharma (Buy, TP: DKK1000.00) - Focus on pipeline progression
We expect an uneventful Q1 report, with investor focus on top-line results from the dapiglutide phase Ib obesity trial (due in Q2), which could help provide clarity on the positioning of the molecule in obesity and inflammation. For petrelintide, we have reduced our peak sales forecast to cUSD10.0bn (cUSD10.8bn) on increased competition from GUBamy. We reiterate our BUY but have cut our target price to DKK1,000 (1,150).
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK900.00) - Subdued prescription growth in Q1
We have updated our model with the latest IQVIA data, and see downside risk to Visible Alpha consensus. We see Q1e global sales for Wegovy of DKK17,898m (c2.2% below consensus) and Ozempic of DKK31,642m (c1.5% below consensus). While a reaffirmation of guidance could offer relief, we have lowered our target price, primarily on lower-than-expected GLP-1 sales. We reiterate our BUY but have cut our target price to DKK900 (1,040).
- Rune Majlund Dahl
Zealand Pharma (Buy, TP: DKK1150.00) - Deal delivery
We are positive on the partnership with Roche for petrelintide and view the financial terms as favourable for Zealand Pharma. While we had included Roche as the partner for petrelintide in our base case, the deal terms are better than we assumed. Thus, we have updated our valuation for petrelintide to DKK731 NPV/share. We reiterate our BUY and have increased our target price to DKK1,150 (1,010), based on our SOTP NPV.
- Rune Majlund Dahl
Zealand Pharma (Buy, TP: DKK1010.00) - Poised for big news
Q4 revenue was DKK9.1m, driven by the Zegalogue licence and development agreement with Novo Nordisk, and EBIT was DKK-399.3m (we forecast DKK-370.1m, consensus DKK-367.6m). The 2025 opex guidance was for DKK2,000m–2,500m, reflecting pipeline progression investments. We expect strong pipeline news flow in H1, including dapiglutide headline results and potentially a petrelintide partnership. We reiterate our BUY and DKK1,010 target price.
- Rune Majlund Dahl
Zealand Pharma (Buy, TP: DKK1010.00) - Focus on partnership discussion...
We expect an uneventful Q4 report, but with investor focus on the ongoing petrelintide partnership discussions. Our base case derives DKK593/share for petrelintide, assuming a profit-sharing agreement in H1. We believe recruitment for the petrelintide phase II trial will be completed in H1 (headline results in Q1 2026e) and look for 2025 opex guidance of DKK1,750m–1,850m. We reiterate our BUY and DKK1,010 target price.
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK1040.00) - Credibility rebuilding
We attended a management roundtable discussion in London today. Highlights included focus on the obesity portfolio with the CagriSema results and launch delay, Amycretin, and early-stage candidates. Management remains confident in its ability to scale beyond 2025, aided by the acquisition of Catalent and the resolution of Wegovy and Ozempic supply issues by 2026. We reiterate our BUY and DKK1,040 target price.
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK1040.00) - Turning point achieved
The company met its full-year guidance, with c26% LCY sales and operating profit growth in Q4. We believe the 2025 guidance for 16–24% LCY sales growth and 19–27% operating profit growth indicates strong operating leverage. At tomorrow’s ‘Meet the Management’ event, we expect GLP-1 supply to be the key focus. We reiterate our BUY and DKK1,040 target price.
e-therapeutics veröffentlicht präklinische Daten zu ETX-148 auf dem EA...
e-therapeutics veröffentlicht präklinische Daten zu ETX-148 auf dem EAHAD 2025 LONDON, Feb. 05, 2025 (GLOBE NEWSWIRE) -- e-therapeutics plc, ein Unternehmen mit Fokus auf der Integration von Rechenleistung und biologischen Daten für die Erforschung lebensverändernder RNAi-Arzneimittel, gab heute bekannt, dass es auf dem Jahreskongress der European Association for Haemophilia and Allied Disorders (EAHAD) vom 4.-7. Februar 2025 neue präklinische Daten präsentieren wird, die nachweislich die Wirksamkeit und Sicherheit von ETX-148 bei Hämophilie A und B in Mausmodellen zeigen. ETX-148 wird zu...
e-therapeutics présentera des données précliniques relatives à l’ETX-1...
e-therapeutics présentera des données précliniques relatives à l’ETX-148 lors de l’édition 2025 du Congrès annuel de l’EAHAD LONDRES, 05 févr. 2025 (GLOBE NEWSWIRE) -- e-therapeutics plc, une entreprise qui conjugue la puissance informatique aux données biologiques en vue de mettre au point des nouveaux médicaments ARNi, annonce ce jour son intention de présenter de nouvelles données précliniques démontrant l’efficacité et la sécurité d’emploi de l’ETX-148 dans des modèles murins d’hémophilie A et B lors du Congrès annuel de l’Association européenne pour l’hémophilie et les troubles appar...
e-therapeutics to Present Preclinical Data on ETX-148 at EAHAD 2025
e-therapeutics to Present Preclinical Data on ETX-148 at EAHAD 2025 LONDON, Feb. 05, 2025 (GLOBE NEWSWIRE) -- e-therapeutics plc, a company integrating computational power and biological data to discover life-transforming RNAi medicines, announced today that it will present new preclinical data demonstrating efficacy and safety of ETX-148 in murine models of haemophilia A and B at the Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD), 4th-7th February 2025. ETX-148 is being developed for the treatment of bleeding disorders and is currently progressin...
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK1040.00) - Wegovy sales hinge on supply
Based on realised US prescriptions, we forecast LCY to be below the 2024 guidance midpoint. Our Q4e sales for Wegovy and Ozempic are below consensus, likely due to a lack of script data among contributors, inventory fluctuations, or different rebate assumptions. We expect 2025 LCY guidance for 15–23% sales growth and 16–24% operating profit growth. We reiterate our BUY and DKK1,040 target price.
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK1040.00) - Disappointing CagriSema data
In REDEFINE-1, CagriSema reached a 22.7% product estimand weight loss, shy of expectations. We expect a launch in 2026, but have lowered our estimate of its sales potential. In our view, the flexible protocol affected efficacy, prompting Novo Nordisk to initiate a new phase III trial in 2025. We reiterate our BUY, but have cut our target price to DKK1,040 (1,150).
- Rune Majlund Dahl
Zealand Pharma (Buy, TP: DKK1010.00) - Glepaglutide uncertainty
The FDA has concluded that Zealand Pharma’s application for glepaglutide in short bowel syndrome did not accommodate its requirements. As a result, Zealand Pharma expects to initiate a phase III trial in 2025 to support approvals ex-EU and provide confirmatory evidence for a regulatory resubmission in the US. We now assume a 48% POS for glepaglutide and have cut our risk-adjusted NPV/share to DKK31. We reiterate our BUY but have cut our target price to DKK1,010 (1,050).
- Rune Majlund Dahl
Novo Nordisk (Buy, TP: DKK1150.00) - Adding extra weight with Catalent
Novo Holdings’ Catalent deal and the resale of three sites to Novo Nordisk has finally cleared. We already had Catalent in our model and forecast it to add a step-up in obesity sales from 2026. In our view, this move underpins the strength of having Novo Holdings’ as the major shareholder. For 2025, we expect guidance for 15–23% LCY sales growth and 14–22% LCY operating profit growth. We reiterate our BUY and DKK1,150 target price.
- Rune Majlund Dahl
Zealand Pharma - Initiation of coverage - Bulking up for the big leagu...
We initiate coverage with a BUY and target price of DKK1,050. We see petrelintide as potentially the first and best-in-class amylin, offering GLP-1-like efficacy but with better tolerability and weight-loss composition. We expect a petrelintide profit-sharing agreement in H1 2025, with Roche as the most likely partner in our view. We see its three obesity candidates having the potential to reach a c8% share in a cUSD227bn market by 2042e.
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