Comme Astérix dans l’album éponyme, Barnier a un chaudron à remplir. Deux mesures pour y parvenir ont « fuité » ces derniers jours dans la presse : rabotage du CIR (Crédit d’impôt Recherche) et hausse « exceptionnelle » de l’impôt des sociétés sur les grands groupes. Nous avons mesuré la sensibilité des 90 et 80 sociétés les plus concernées dans notre univers de couverture à ces deux mesures. 20 sociétés ont un CIR > 5% de leur EBIT et 22 sociétés verraient leurs BPA baisser de plus d...
Like Astérix in the album of the same name, Michel Barnier has a cauldron to fill. Two measures to manage this have “leaked” in the press in the last few days: a reduction in the CIR research tax credit and an exceptional tax increase on large companies. We measured the sensitivity to these two measures of the 90 and 80 companies most concerned in our coverage universe. 20 companies have a CIR >5% of their EBIT and 22 companies would see their EPS fall by more than 5% due to the addit...
>Development focused on 5 therapeutic areas and 11 diseases - At its Pharma Day yesterday, Roche presented its new strategy which is now focused on 1/ five therapeutic areas (cardiovascular/metabolic, oncology/haematology, neurology, immunology and ophthalmology) representing 80% of future pharma industry growth and 2/ eleven pathologies (including breast cancer, haemophilia, multiple sclerosis, obesity, etc.) in which Roche believes it has the capacity to bring to th...
>Développement focalisé sur 5 aires thérapeutiques et 11 pathologies - Lors de son Pharma Day tenu hier, Roche a présenté sa nouvelle stratégie désormais focalisée sur 1/cinq aires thérapeutiques (cardiovasculaire/métabolique, oncologie/hématologie, neurologie, immunologie et ophtalmologie) représentant 80% de la croissance future de l’industrie pharma et 2/ onze pathologies (dont cancer du sein, hémophilie, sclérose en plaques, obésité, etc.) dans lesquelles Roche pe...
When the BoJ raised rates in March, it had been 17 years since it had last done so, though the world was very different then. While the July rate hike was unlikely to move the economic needle, the question now is what else might follow the subsequent financial market maelstrom. Pelham Smithers discusses the outlook for Japan’s macro environment, what new fiscal policies the new PM might introduce, how the BoJ might react and the all-important trend in corporate earnings. This then leads us to...
>Differentiated clinical profiles of CT-388 and CT-996 not validated at this stage - At last week's EASD, Roche presented new phase I clinical data for its two lead compounds in obesity, including the following:CT-388 (GIP/GLP-1; weekly injection): data at 24 weeks showed a weight reduction of 18.9% at the highest dose, making CT-388 one of the most potent products currently in development. For example, weight loss was 17.5% for Lilly's retatrutide at 24 weeks ...
>Profils cliniques différenciés de CT-388 et CT-996 non validés à ce stade - Dans le cadre du congrès de l’EASD qui s’est tenu la semaine dernière, Roche a présenté de nouvelles données cliniques de phase 1 pour ses deux actifs phares dans l’obésité, dont nous retenons les points suivants :CT-388 (GIP/GLP-1 ; injection hebdomadaire) : les données à 24 semaines montrent une réduction de poids de 18.9% à la dose la plus forte ce qui positionne CT-388 parmi les pr...
Two Directors at Gilead Sciences Inc sold/sold after exercising options 50,603 shares at between 83.782USD and 84.500USD. The significance rating of the trade was 75/100. Is that information sufficient for you to make an investment decision? This report gives details of those trades and adds context and analysis to them such that you can judge whether these trading decisions are ones worth following. Included in the report is a detailed share price chart which plots discretionary trades by all...
After a stress episode in the first few days of the month, the equity markets finished August on a gain. US markets ended slightly ahead of Europe, thanks notably to the latest good US GDP numbers, but this performance is erased by the strong rise of the euro. The main driver was short rates falling in anticipation of rate cuts by central banks, with 2-year rates coming close to 10-year rates in the US and Europe. Tech stocks took a hit but less so than in July, and the two worst per...
Après leur stress tout début août, les marchés actions finissent le mois dans le vert. Les marchés américains terminent légèrement devant l’Europe, notamment grâce aux derniers bons chiffres du PIB USA, mais cette performance est effacée par la forte remontée de l’euro. Ce sont surtout les taux courts qui ont reculé, anticipant des baisses de taux par les banques centrales, le 2 ans revenant proche du 10 ans aux USA comme en Europe. Les valeurs technologiques ont souffert mais moins q...
>Discount de la première liste Medicare enfin dévoilé (-66% en médiane) - Le 15 août dernier, l’administration Biden-Harris a officiellement communiqué le rabais qui sera appliqué aux 10 médicaments (voir tableau en deuxième page) de la première liste établie par Medicare dans le cadre de l’IRA. Il ressort donc de ces négociations un discount appliqué sur le list price allant de -38% (Imbruvica ; oncologie) à -79% (Januvia ; diabète) avec une médiane à -66%, ce qui d...
>Discount for the first Medicare list finally announced (median of -66%) - On 15 August, the Biden-Harris administration officially announced the discount that will be applied to the 10 drugs (see the list on page 2) of the first list set out by Medicare within the IRA framework. The result of the negotiations is an applied discount to the list price ranging from -38% (Imbruvica, oncology) to -79% (Januvia, diabetes) with a median of -66%, which should generate savin...
Summary Marketline's Taisho Pharmaceutical Holdings Co Ltd Mergers & Acquisitions (M&A), Partnerships & Alliances and Investments report includes business description, detailed reports on mergers and acquisitions (M&A), divestments, capital raisings, venture capital investments, ownership and partnership transactions undertaken by Taisho Pharmaceutical Holdings Co Ltd - Mergers & Acquisitions (M&A), Partnerships & Alliances since January2007. Marketline's Company Mergers & Acquisitions (M&A), ...
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