Inventiva Positive DMC recommendation for lanifibranor in NASH/MASH
Inventiva announced the positive recommendation from the 5th scheduled meeting of the data monitoring committee (DMC) to continue the phase 3 (NATiV3) trial evaluating lanifibranor (pan-PPAR agonist) in patients with NASH/MASH without modification to the current trial protocol. This is of particular note given that one of the criteria for access to future tranches from the recently announced € 348m financing is dependent on a positive DMC recommendation. The company continues to recruit patients in the phase 3 trial of lanifibranor in NASH/MASH and we look forward to completion of enrolment in 1H25, an important event that would provide timeline certainty for the topline readout expected in 2H26. We reiterate our BUY rating and € 7 TP.Inventiva is a clinical stage biotechnology research company delivering therapies in the areas of oncology, fibrosis and rare diseases. The most advanced clinical programs (IVA337 for systemic sclerosis in Non-Alcoholic Steato-Hepatitis and IVA336 for Maroteaux-Lamy syndrome-MPS VI) have demonstrated efficacy in relevant in vivo and in vitro models as well as safety in phase I and phase II clinical trials. Using its in-house drug discovery platform, which covers target validation, screening, chemistry, ADME and pharmacology, Co. is developing an internal oncology and fibrosis discovery pipeline with approaches centered on transcription factors, epigenetics targets and nuclear receptors.
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