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GSK: 1 director

A director at GSK sold 6,000 shares at 1,702p and the significance rating of the trade was 59/100. Is that information sufficient for you to make an investment decision? This report gives details of those trades and adds context and analysis to them such that you can judge whether these trading decisions are ones worth following. Included in the report is a detailed share price chart which plots discretionary trades by all the company's directors over the last two years clearly showing Close p...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

GSK - It’s Not Sexy But It Is a BUY (TP £19 [£14.50], 14 pgs)

Following new analysis on current growth drivers & upcoming pipeline readouts, we upgrade our 2028 revenues by £2.5bn & believe GSK can deliver 11% CAGR EPS growth 2024-27 leaving us 7% above consensus 2027 EPS. Whilst we believe 2029-31 is an unfillable hole & justifies a low multiple on Pharma, this is more than in the price and near-term momentum will likely drive the shares higher. The Zantac overhang clearing, some pipeline catalysts & the potential for fresh management coupled with near-te...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

EU Pharma - 2024 Year Ahead (28 pgs)

For EU Pharma, 2024 is likely to be characterised by EPS revisions, a handful of new launches & sluggish EPS growth for a number of names. The relative lack of pipeline catalysts makes forecasting sales and EPS much more important than for 2023. We identify 4 key issues to watch for: 1) Medicaid AMP cap removal, 2) Higher tax costs, 3) Higher debt costs & 4) a handful of very specific company issues that could make a material difference to performance (Novo: Wegovy supply, GSK: litigation, SAN: ...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

GSK - 30% EBIT Decline 2027-29

Our analysis of the impact of IRA on the 6 EU Pharma names shows GSK is most exposed this decade & we cut to HOLD. Shingrix & Trelegy US price cuts may account for a 7% EBIT hit in 2028. This happens at the same time as the ViiV patent losses leading to ~1/3 of group EBIT being lost 2027-29. We argue that GSK should aggressively cut costs today to boost M&A firepower to try to plug the hole. In the absence of this, we see limited ability to minimise the end of decade earnings losses. We also see...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

EU Pharma - IRA Impact Analysed (Thematic Research, 16pgs)

The IRA is a complex piece of legislation that will materially cut some US drug prices. With the IRA newsflow set to amp up, our analysis of the impact on EU Pharma shows that the IRA has a negligible effect on value. We calculate that the IRA negotiations will reduce sector sales by 1.5% by 2030, driving a 4% EBIT impact, but just a ~1% NPV impact. The only concern we have is if pricing in the commercial channel is also affected. We show that in this scenario, where price in commercial is the s...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

Novartis - Readying Itself for GSK Bid? (BUY, TP CHF97 [90], 15 pgs)

We discuss whether Novartis is readying its war chest for a large merger. Novartis has shed ~$100bn of assets since 2014 & by the end of 2023 will be almost net cash. Recent rumours of a respiratory divestment has led us to explore what a GSK acquisition would look like for Novartis. Re-entering Vaccines & entering Virology with world-leading franchises would help diversify away from the crowded and increasingly risky oncology space. The deal could be >40% accretive & all cash with pro forma net...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

EU Pharma - IRA Could be EBIT Tailwind in 2023 (7 pgs)

Given the forecasted 10% CPI-U US inflation this year, we show that the new Inflation Reduction Act could provide a low-single digit EBIT tailwind in 2023 for EU Pharma as the industry is able to take higher price rises than we have seen in recent years. This comes at a time when wage inflation could add some modest pressure to Pharma cost bases [here] in 2023, so is a welcome partial offset. Our analysis shows that Roche could have the greatest tailwind whilst GSK the least. For access to the f...

Team Pharma
  • Team Pharma

ODDO : A beneficial forex trend for Sanofi, GSK and Novo Nordisk

>Q3 marked by profit taking and the Zantac scandal - The pharma sector was impacted in Q3 by profit taking following the excellent H1 performance (+8% vs STOXX600 -17%), as well as by the Zantac scandal (Sanofi and GSK) and to a lesser extent the Nexium affair (AstraZeneca) which put the legal risks intrinsic to the sector back in the spotlight. The performance for STOXX600 Healthcare stands at -7.6% over the quarter vs -4.8% for the STOXX600. The median performance i...

Team Pharma
  • Team Pharma

ODDO : Une évolution des changes bénéfique pour Sanofi, GSK et Novo No...

>T3 marqué par une prise de profits et le scandale Zantac - Le secteur Pharma a été impacté au T3 par une prise de profits suite à l’excellente performance du S1 (+8% vs STOXX600 -17%) et également par le scandale Zantac (Sanofi et GSK) et dans une moindre mesure l’affaire Nexium (AstraZeneca) qui ont remis sur le devant de la scène les risques intrinsèques au secteur liés aux litiges. La performance du STOXX600 Healthcare ressort à -7.6% sur le trimestre vs -4.8% po...

Team Pharma
  • Team Pharma

ODDO : Pharma set to remain a defensive sector with an attractive grow...

Since the beginning of the year, the sector has played its defensive role in an uncertain geopolitical and macroeconomic context (Stoxx 600 Healthcare -14.4% vs -18.0% for Stoxx 600). We think that the recent profit taking which lowered 2023e P/E from 14.4x to 13.3x between 1 July and 23 September represents an opportunity. Moreover, in the run-up to 2023, set to be rich in clinical data, we prefer stocks that have not seen their short-term growth compromised, like AstraZeneca (T...

Team Pharma
  • Team Pharma

ODDO : La Pharma restera un secteur défensif avec un profil de croissa...

Depuis le début de l’année, le secteur a joué son rôle défensif dans un contexte géopolitique et macroéconomique incertain (Stoxx 600 Healthcare -14,4% vs -18,0% pour le Stoxx 600). Nous considérons que les prises de profits récentes qui ont conduit le PE 23 à baisser de 14,4x à 13,3x entre le 1er juillet et le 23 septembre représentent une opportunité. Aussi en amont d’une année 2023 chargée en clinique, sont à privilégier les valeurs dont la croissance CT n’est pas mise à mal, ...

Team Pharma
  • Team Pharma

ODDO : Pharma set to remain a defensive sector with an attractive grow...

Since the beginning of the year, the sector has played its defensive role in an uncertain geopolitical and macroeconomic context (Stoxx 600 Healthcare -14.4% vs -18.0% for Stoxx 600). We think that the recent profit taking which lowered 2023e P/E from 14.4x to 13.3x between 1 July and 23 September represents an opportunity. Moreover, in the run-up to 2023, set to be rich in clinical data, we prefer stocks that have not seen their short-term growth compromised, like AstraZeneca (T...

Team Pharma
  • Team Pharma

ODDO : La Pharma restera un secteur défensif avec un profil de croissa...

Depuis le début de l’année, le secteur a joué son rôle défensif dans un contexte géopolitique et macroéconomique incertain (Stoxx 600 Healthcare -14,4% vs -18,0% pour le Stoxx 600). Nous considérons que les prises de profits récentes qui ont conduit le PE 23 à baisser de 14,4x à 13,3x entre le 1er juillet et le 23 septembre représentent une opportunité. Aussi en amont d’une année 2023 chargée en clinique, sont à privilégier les valeurs dont la croissance CT n’est pas mise à mal, ...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

EU Pharma - Best Placed for 2023 (21 pgs)

EU Pharma has one of the best outlooks into 2023 based on our detailed analysis of cost structures, leading us to believe that there is a greater potential for upgrades than downgrades. Our breakdown of cost base by company allows us to assess inflationary pressures into 2023. We estimate there is a 2-5% incremental hit to our existing 2023 EBIT forecasts when accounting for higher-than-trend wage inflation and energy costs. However, we show the industry has more pricing power than most assume &...

Dominic Rose ... (+2)
  • Dominic Rose
  • Naresh Chouhan

Sanofi - Zantac Settlement Deep-Dive (BUY, TP EUR132 [135], 14 pgs)

To assess the risk for Sanofi (and GSK) we analyse various elements of the potential settlements that the industry may make on Zantac and show a timeline of events and ownership. There are considerable barriers that have been implemented for plaintiffs, including tumour type (we estimate only 12% of cancer diagnoses are included), proof of Zantac use for 12 months, statute of limitations and severity of injury, amongst others. We show the scientific evidence is unclear as to whether Zantac cause...

Ahmed Ben Salem ... (+2)
  • Ahmed Ben Salem
  • Bruno Cavalier

ODDO BHF SECURITIES MORNING NEWS – DETAILED COMMENTS 07/27/2022

In the spring, the German economy was just on the verge of recession. Since then, according to various business climate surveys, it has made… a step forward. A contraction of activity seems unavoidable. Its duration and extent will depend on the developments of the energy crisis. Germany is exposed to the risk of a gas shortage, the intensity of which depends mainly on two factors, one geopolitical (the magnitude of Russian gas shutoff), the other technical (the diversification via ot...

Ahmed Ben Salem ... (+2)
  • Ahmed Ben Salem
  • Bruno Cavalier

ODDO BHF SECURITIES MORNING NEWS – COMMENTAIRES DETAILLES 27/07/2022

Au printemps, l’économie allemande était au bord de la récession. Depuis, si l’on en croit les enquêtes de climat des affaires, elle a fait… un grand pas en avant. Une contraction de l’activité semble donc inéluctable. Sa durée et son ampleur seront dictées par les développements de la crise énergétique. L’Allemagne est exposée à un risque de pénurie en gaz dont l’intensité dépend surtout de deux facteurs, l’un géopolitique (l’ampleur des baisses de livraisons de gaz russe), l’autre t...

Damien Choplain ... (+2)
  • Damien Choplain
  • Martial Descoutures

GlaxoSmithKline : Q2 beats forecasts, guidance raised

>Xevudy and Shingrix drive growth - GSK reported a Q2 that beat estimates for sales (+10% vs consensus) and its core EPS (+18% vs consensus), thanks to a strong contribution from Xevudy (£ 466m vs consensus £ 97m) and significant rebound at Shingrix (+148%) in line with Q1 (+114%). Global sales were up 13% CER. After a tricky year for Shingrix, we see a very strong rebound in drug sales far above the consensus (£ 731m vs consensus of £ 610m). Group core EBIT was up by...

Damien Choplain ... (+2)
  • Damien Choplain
  • Martial Descoutures

GlaxoSmithKline : T2 au-dessus des attentes, guidance relevée

>Xevudy et Shingrix tirent la croissance - GSK publie un T2 au-dessus des attentes au niveau des ventes (+10% vs Cs) et de son core EPS (+18% vs Cs), grâce à une forte contribution de Xevudy (466 M£ vs Cs 97 M£) et d’un rebond significatif de Shingrix (+148%) dans la lignée du T1 (+114%). Les ventes globales ressortent en hausse de 13% CER. Après une année délicate pour Shingrix, nous observons un très fort rebond des ventes du médicament bien supérieur au consensus (...

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